陕西中医2025，Vol.46Issue(10)：1366-1370,5.DOI:10.3969/j.issn.1000-7369.2025.10.013
清肺养阴益气汤对晚期非小细胞肺癌化疗减毒增效作用及对患者中医证候和机体免疫功能的影响
Effect of Qingfei Yangyin Yiqi decoction on reducing toxicity and enhancing efficacy of chemotherapy in advanced non-small cell lung cancer and its impact on patients' traditional Chinese medicine syndrome and immune function
摘要
Abstract
Objective:To clarify the effect of Qingfei Yangyin Yiqi decoction on reducing toxicity and enhancing efficacy of chemotherapy for advanced non-small cell lung cancer,as well as its impact on patients'traditional Chinese medicine syndromes and immune function.Methods:This study included advanced non-small cell lung cancer subjects who met the inclusion criteria for chemotherapy and randomly divide them into a control group(with a sim-ple chemotherapy regimen)and a combined group(treated with Qingfei Yangyin Yiqi decoction in addition to inter-vention in the control group).The outcome measures included:comparison of clinical efficacy and specific scores of traditional Chinese medicine syndrome scores;serum tumor markers of carcinoembryonic antigen(CEA),neuron-specific enolase(NSE),etc.;cytokines of interleukin(IL)-1β,IL-6 and IL-10,and immune function levels;and safety revealed by adverse reactions.Results:The objective response rate of the combined group was 56.41％,significantly higher than that of 33.33％in the control group,and the difference was statistically significant(P＜0.05).The scores of traditional Chinese medicine main symptoms,secondary symptoms,and tongue symptoms in the combined group were significantly higher than those in the control group,and the differences were statistically significant(all P＜0.05).Furthermore,after treatment,the levels of CEA,NSE,squamous cell carcinoma antigen(SCCAg),IL-6 and IL-1β,and CD8+in both groups decreased compared to before treatment;while IL-10,CD3+,CD4+levels,and CD4+/CD8+were increased compared to before treatment(all P＜0.05);moreover,after treatment,the levels of CEA,NSE,SCCAg,IL-6 and IL-1β,and CD8+in the combination group were lower than those in the control group;while IL-10,CD3+,CD4+levels,and CD4+/CD8+were higher than those in the control group,with statistically sig-nificant differences(all P＜0.05).During the treatment period,the rates of nausea and vomiting,diarrhea,thrombo-cytopenia,and myelosuppression in the combined group were significantly lower than those in the control group,and the differences were statistically significant(all P＜0.05).Conclusion:For patients with advanced non-small cell lung cancer undergoing chemotherapy,Qingfei Yangyin Yiqi decoction can play roles in reducing toxicity and increasing ef-ficiency,which can improve traditional Chinese medicine syndromes,enhance immune function,slow down inflamma-tory reactions,and improve patients' quality of life.This therapeutic scheme is safe and effective.关键词
晚期非小细胞肺癌/清肺养阴益气汤/化疗/减毒增效/中医证候/免疫功能Key words
Advanced non-small cell lung cancer/Qingfei Yangyin Yiqi decoction/Chemotherapy/Reduced toxicity and increased efficiency/Traditional Chinese medicine syndrome/Immune function分类
医药卫生引用本文复制引用
熊乙霓,郭旭,陈明明..清肺养阴益气汤对晚期非小细胞肺癌化疗减毒增效作用及对患者中医证候和机体免疫功能的影响[J].陕西中医,2025,46(10):1366-1370,5.基金项目
四川省中医药管理局科学技术研究专项课题(2024MS368) （2024MS368）
