世界科学技术-中医药现代化2025，Vol.27Issue(10)：2810-2816,7.DOI:10.11842/wst.20250427011
"筋骨失衡,以筋为先"视角下椎间盘退变对脊柱稳定性影响的生物力学机制
Biomechanical Mechanism Discussion of Intervertebral Disc Degeneration on Spinal Stability Based on the Theory of"Muscle and Bone Imbalance,Putting Muscle First"
摘要
Abstract
The concept of"musculoskeletal imbalance with soft tissue primacy"posits that tendon injury induced by intervertebral disc degeneration constitutes the core pathogenesis of spinal musculoskeletal imbalance.This study systematically elucidates the pathological mechanisms through which tendon injury leads to spinal instability by integrating traditional Chinese medicine(TCM)"musculoskeletal balance"theory with contemporary biomechanical research on disc degeneration.In the process of intervertebral disc degeneration,the change of stress distribution revealed by modern biomechanics is highly consistent with the TCM principle of"tendon impairment affecting bone".Finite element analysis revealing the"stability-instability-restabilization"process further validates the pathological progression from musculoskeletal imbalance to rebalance.This integrated TCM-Western medicine perspective establishes a novel theoretical framework for predicting disease progression and developing personalized therapeutic strategies,particularly in guiding clinical practice of"treating bone disorders through tendon regulation".关键词
筋骨失衡/脊柱退行性疾病/椎间盘退变/生物力学/中西医结合Key words
Musculoskeletal imbalance/Degenerative spinal diseases/Intervertebral disc degeneration/Biomechanics/Integrated traditional Chinese and Western medicine分类
医药卫生引用本文复制引用
吴亚东,张治国,李静,齐晓艳,鲁玉州,李念虎.."筋骨失衡,以筋为先"视角下椎间盘退变对脊柱稳定性影响的生物力学机制[J].世界科学技术-中医药现代化,2025,27(10):2810-2816,7.基金项目
山东省自然科学基金创新发展联合基金项目(ZR2021LZY006):基于"筋骨平衡"视角探索独活寄生汤调控P38MAPK信号通路干预腰椎间盘退变的保护机制研究,负责人:吴亚东. （ZR2021LZY006）
