陕西医学杂志2025，Vol.54Issue(10)：1343-1348,6.DOI:10.3969/j.issn.1000-7377.2025.10.008
Glasgow预后评分、C反应蛋白/白蛋白与全球急性冠状动脉登记事件评分对急性非ST段抬高型心肌梗死患者PCI术后院内不良预后的预测价值
Predictive value of glasgow prognostic score,C-Reactive protein/Albumin,and GRACE score for adverse in-hospital prognosis after PCI in patients with acute Non-ST-Segment elevation myocardial infarction
摘要
Abstract
Objective:Evaluate the predictive value of Glasgow Prognostic Score(GPS),C-reactive protein/albu-min(CAR),and Global Acute Coronary Event Registry(GRACE)score for major cardiovascular adverse events(MACE)in patients with acute non ST segment elevation myocardial infarction(NSTEMI).Methods:293 NSTEMI patients who underwent percutaneous coronary intervention(PCI)were divided into MACE group(n=56)and non MACE group(n=237).Calculate GPS,CAR,and GRACE scores based on patient clinical data and laboratory test data.Using binary logistic regression to analyze the influencing factors of MACE occurrence,and comparing the pre-dictive value of GPS,CAR,and GRACE scores for MACE occurrence through receiver operating characteristic(ROC)curve analysis.Perform subgroup analysis of different GRACE scores,GPS,CAR,and MACE using a binary log genomic regression model.Results:A total of 293 NSTEMI patients who underwent emergency PCI were includ-ed.Age,smoking history,GRACE score,GPS,and CAR are independent influencing factors for the occurrence of MACE.The ROC curve analysis results showed that all three have certain predictive value for the occurrence of MACE.The area under the curve(AUC)of GPS was 0.721(95％CI:0.642-0.800),higher than CAR[AUC=0.672(95％CI:0.586-0.757)],and similar to GRACE score(AUC=0.729,95％CI:0.651-0.807).The maximum com-bined AUC of the three was 0.818(95％CI:0.752-0.884),with sensitivity and specificity of 67.90％and 84.00％,respectively.According to the third quartile method,GRACE score,GPS,and CAR were divided into three groups(Q1-Q3).The incidence of MACE in the Q1,Q2,and Q3 groups was statistically significant(all P＜0.05).After ad-justing for confounding factors,the results showed that the risk of MACE in both Q2 and Q3 groups was higher than that in Q1 group(all P＜0.001).Conclusion:GPS and CAR are both independent risk factors for NSTEMI in-hospi-tal MACE,and their predictive efficacy can be improved when combined with GE ACE score.关键词
Glasgow预后评分/C反应蛋白/白蛋白/GRACE评分/急性非ST段抬高型心肌梗死/主要心血管不良事件/预测Key words
Glasgow prognostic score/C-reactive protein/Albumin/GRACE score/Acute non-ST-segment ele-vation myocardial infarction/Major adverse cardiovascular events/Prediction分类
医药卫生引用本文复制引用
马晓雨,潘思雨,李若水,纵静,钱文浩..Glasgow预后评分、C反应蛋白/白蛋白与全球急性冠状动脉登记事件评分对急性非ST段抬高型心肌梗死患者PCI术后院内不良预后的预测价值[J].陕西医学杂志,2025,54(10):1343-1348,6.基金项目
国家自然科学基金资助项目(82300380) （82300380）
