沈阳医学院学报2025，Vol.27Issue(5)：449-453,460,6.DOI:10.16753/j.cnki.1008-2344.2025.05.001
维生素D缺乏与认知下降的研究进展
Research progress on vitamin D deficiency and cognitive decline
摘要
Abstract
As a common nutrient,vitamin D participates in neuronal development,synaptic plasticity and neuroinflammation by binding to vitamin D receptors.Cognitive decline,a prodromal stage of mild cognitive impairment and Alzheimer's disease,has become a major global public health challenge.It not only seriously affects the quality of life of patients,increases the burden of family care,but also brings heavy pressure to the social economy.Recent studies have shown that vitamin D deficiency may be potentially associated with cognitive decline.This article systematically reviews the existing research evidence,focusing on the potential biological mechanisms by which vitamin D affects cognitive function,key findings from preclinical studies(animal experiments),as well as the current status and controversies in population studies.The aim is to provide theoretical basis for exploring related mechanisms and clinical intervention.关键词
维生素D/认知功能/认知障碍Key words
vitamin D/cognitive decline/cognitive impairment分类
医药卫生引用本文复制引用
陶威,张莹..维生素D缺乏与认知下降的研究进展[J].沈阳医学院学报,2025,27(5):449-453,460,6.基金项目
辽宁省高等学校创新人才资助项目(No.LR2016012) （No.LR2016012）
