沈阳医学院学报2025,Vol.27Issue(5):527-534,8.DOI:10.16753/j.cnki.1008-2344.2025.05.015
微生物-肠-脑轴双向调控动物认知行为的研究进展
Research progress on bidirectional regulation of animal cognitive behavior by microbial-gut-brain axis
摘要
Abstract
Cognitive impairment is one of the manifestations of nervous system injury,which is mainly closely related to neurodegeneration,and the incidence rate is increasing year by year,which has seriously affected the health level of the population.The gut microbiota plays an important role in the health of the body and participates in the regulation of the cognitive behavior of body.The microbiome-gut-brain axis acts as a bridge connecting gut microbiota and the nervous system,and plays a regulatory role between gut microbiota and the nervous system.Therefore,this review summarizes the latest progress in the effects of gut microbiota and nervous system on the cognitive ability of body through the bidirectional regulation of neurotransmitters,gut microbiota derivatives,neuroinflammation,oxidative stress,autophagy and their crosstalk through the microbial-intestinal-brain axis,and providing a reference for the clinical research of targeted transplantation of gut microbiota for preventing and treating cognitive disorders.关键词
微生物-肠-脑轴/神经炎症/氧化应激/自噬/认知行为Key words
microbiota-gut-brain axis/neuroinflammation/oxidative stress/autophagy/cognition behaviour分类
医药卫生引用本文复制引用
王宇强,路旭鑫,邓翠娥,毛英先,张巍伟..微生物-肠-脑轴双向调控动物认知行为的研究进展[J].沈阳医学院学报,2025,27(5):527-534,8.基金项目
国家自然科学基金项目(No.82304860) (No.82304860)
沈阳医学院大学生科研项目(No.20249034) (No.20249034)