陕西科技大学学报2025，Vol.43Issue(5)：8-15,22,9.
胶原/羧甲基壳聚糖纳米复合纤维基水凝胶的制备及其性能
Preparation and characterization of collagen/carboxymethyl chitosan composited nanofibrous hydrogels
摘要
Abstract
Collagen(COL)/carboxymethyl chitosan(CMCS)nanofibrous composited hydro-gels were prepared by blending collagen and CMCS at various COL∶CMCS ratios and subse-quent self-assembly.Carboxyl and hydroxyl groups of CMCS were successively interacted with amide groups of collagen via hydrogen bonds,which were the dominated interaction.Then the electrostatic interaction occurred between carboxylate of CMCS and basic amino acid residues of collagen.With increasing CMCS content,the binding stability of CMCS with collagen and collagen self-assembly property firstly increased and then decreased.At a COL∶CMCS ratio of 4∶6,the collagen self-assembly was optimal,and the formed nanofibrils with D-period possessed larger diameters.Therefore,the composited nanofibrils had better stability,and the properties of the composited nanofibrous hydrogels were improved.For ex-ample,thermal denaturation temperature of the composited hydrogel was 22.8 ℃ higher than that of pure collagen;additionally,the swelling ratio and degradation degree were 14 930.4％±340.7％and 53.4％±2.9％,respectively.The material has potential application prospects in the field of wound dressings and drug carriers.关键词
胶原/羧甲基壳聚糖/纳米复合纤维基水凝胶/自组装Key words
collagen/carboxymethyl chitosan/composited nanofibrous hydrogel/self-assem-bly分类
化学化工引用本文复制引用
田振华,郝钏宇,赵文杰,沈妮,高盼盼,张雷..胶原/羧甲基壳聚糖纳米复合纤维基水凝胶的制备及其性能[J].陕西科技大学学报,2025,43(5):8-15,22,9.基金项目
国家自然科学基金项目(22278256,22108166) （22278256,22108166）
陕西省科学技术协会青年人才托举计划项目(20230626) （20230626）
陕西省西安市科学技术协会青年人才托举计划项目(959202313003) （959202313003）
