刑事技术2025，Vol.50Issue(5)：469-474,6.DOI:10.16467/j.1008-3650.2024.0068
毒品缴获物中哌嗪类新精神活性物质4F-MBZP的分析
Analysis of Piperazine-type New Psychoactive Substance 4F-MBZP in Seized Drugs
摘要
Abstract
This paper aims to confirm the new psychoactive substance l-(4-fluorobenzyl)-4-methylpiperazine(4F-MBZP)through a combination of multiple technologies.After ultrasonic extraction with methanol and separation by preparative liquid chromatography,the target was analyzed using a combination of gas chromatography-mass spectrometry(GC-MS),liquid chromatography-quadrupole/time-of-flight tandem mass spectrometry(LC-Q-TOF-MS/MS),Fourier transform infrared spectroscopy(FTIR)and nuclear magnetic resonance hydrogen spectroscopy(1H-NMR),respectively.Through GC-MS analysis,the main characteristic fragment ions of the unknown compound with a retention time of 9.78 min were m/z 208.1,164.1,109.1 and 99.1;By means of LC-Q-TOF-MS/MS detection,the quasi-molecular ion peak of the unknown compound was determined to be m/z 209.286 4,and the main characteristic ion fragments obtained by MS2 were m/z 189.183 0,109.176 9,99.452 0 and 83.387 1;The infrared characteristic absorption peaks of the target measured by FTIR analysis were 3 517.1,2 981.5,2 943.4,1 603.9,1 517.3,1 232.0,1 168.6,1 080.2,827.8 and 766.9 cm-1,indicating that the molecular structure of the suspicious compound contains functional groups including benzene ring,methyl,methylene,and C-N;After further analysis of proton attribution in the unknown compound structure by 1H-NMR and comparison with relevant literature that has been publicly reported,it was confirmed that the unknown compound is a new psychoactive substance called 4F-MBZP.This method is expected to be used in qualitative analysis of 4F-MBZP in seized drugs with simple operation and high accuracy,while providing reference for the detection and identification of new drugs.关键词
毒品/新精神活性物质/1-(4-氟苄基)-4-甲基哌嗪/液相色谱-四极杆/飞行时间串联质谱/核磁共振Key words
drug/new psychoactive substance/1-(4-fluorobenzyl)-4-methylpiperazine(4F-MBZP)/liquid chromatography-quadrupole/time-of-flight tandem mass spectrometry(LC-Q-TOF-MS/MS)/nuclear magnetic resonance(NMR)分类
社会科学引用本文复制引用
李亚庆,康刚,麦宝华,陈深树,程良红,焦台风..毒品缴获物中哌嗪类新精神活性物质4F-MBZP的分析[J].刑事技术,2025,50(5):469-474,6.基金项目
深圳市科技计划(JSGG20210802152810032) （JSGG20210802152810032）
