刑事技术2025，Vol.50Issue(5)：489-495,7.DOI:10.16467/j.1008-3650.2024.0099
GC-MS、GC-MS/MS检测毒品和毛发中甲喹酮、依他喹酮和甲氧喹酮
Determination of Methaqualone,Etaqualone,and 2-Methoxyqualone in Suspected Drugs and Hair by GC-MS and GC-MS/MS
摘要
Abstract
GC-MS and GC-MS/MS analytical methods were developed for the simultaneous detection of three 4(3H)-quinazolinone abused substances,including methaqualone,etaqualone,and 2-methoxyqualone,and applied to the analysis of suspected drugs and the hair of abusers,respectively.The standard solutions of methaqualone,etaqualone,and 2-methoxyqualone were analyzed by using the selected ion monitoring(SIM)and multiple reaction monitoring(MRM)modes,respectively,to determine the characteristic fragment ions and characteristic ion pairs of the three substances.The so established two methods were used to test the suspected drugs and hair samples in the actual cases.The established GC-MS analytical method detected components of methaqualone,etaqualone,and 2-methoxyqualone in the suspected drugs at levels of 11 μg/mg,4.3 μg/mg,and 2.5 μg/mg,respectively.The established GC-MS/MS analytical method detected methaqualone,etaqualone,and 2-methoxyqualone in the hair at levels of 148 ng/mg,565 pg/mg,and 58.2 ng/mg,respectively.The detection methods of GC-MS and GC-MS/MS established in this study are simple,rapid,and accurate,which can provide a reliable scientific basis for the detection of methaqualone,etaqualone,and 2-methoxyqualone in the suspected drugs and the hair of abusers.关键词
法医毒物学/4(3H)-喹唑啉酮类滥用物质/疑似毒品/毛发/气相色谱-质谱法(GC-MS)/气相色谱-串联质谱法(GC-MS/MS)Key words
forensic toxicology/4(3H)-quinazolinone substances/suspected drugs/hair/GC-MS/GC-MS/MS分类
社会科学引用本文复制引用
王猛超,奇海涛,赵崐迪,代茵茵,张晓龙,陈雨轩,许文,阿民勿日他,刘金磊,张榆梓..GC-MS、GC-MS/MS检测毒品和毛发中甲喹酮、依他喹酮和甲氧喹酮[J].刑事技术,2025,50(5):489-495,7.基金项目
国家自然科学基金项目(82360335) （82360335）
内蒙古医科大学英才培育项目(YCPY2023114) （YCPY2023114）
