云南民族大学学报（自然科学版）2025，Vol.34Issue(5)：538-544,630,8.DOI:10.3969/j.issn.1672-8513.2025.05.005
基于网络药理学研究人参抗辐射损伤的作用机制
The mechanism of ginseng against radiation damage based on network pharmacology
摘要
Abstract
This study explored the active ingredients and protective mechanisms of ginseng against radiation damage using network pharmacology and molecular docking techniques.Through TCMSP,22 active ingredients of ginseng and their corresponding targets were screened out.Combined with radiation damage targets from databases such as GeneCards,51 common key targets were obtained.Cytoscape was used to construct a regulatory network,and the String database was used to build a PPI network.According to the degree value,4 key active ingredients were screened out,including protein kinase B1,Caspase-3,interleukin-1β,and prostaglandin synthase 2.Enrichment analysis via R software showed that the active ingredients of ginseng are mainly involved in signaling pathways such as tumor necrosis factor,IL-17,MAPK,and apoptosis.Molecular docking indicated that the 4 active ingredients have strong binding ability to the target proteins.The study preliminarily showed that ginseng may exert anti-radiation damage effects through kaempferol,inermin,beta-sitosterol,and stigmasterol by regulating the aforementioned pathways as well as signaling pathways such as Toll-like receptors and PI3K/Akt.关键词
人参/辐射损伤/辐射防护/网络药理学/分子对接Key words
ginseng/radiation damage/radiation protection/network pharmacology/molecular docking分类
医药卫生引用本文复制引用
李建华,王志鹏,刘欢,高洁,秦秀军,刘晓明,李建国..基于网络药理学研究人参抗辐射损伤的作用机制[J].云南民族大学学报（自然科学版）,2025,34(5):538-544,630,8.基金项目
山西省自然科学研究面上项目(202103021224447). （202103021224447）
