云南民族大学学报（自然科学版）2025，Vol.34Issue(5)：545-550,6.DOI:10.3969/j.issn.1672-8513.2025.05.006
高尿酸血症模型动物的研究进展
Recent progress in the research of model animals with hyperuricemia
摘要
Abstract
Animals with hyperuricemia are the foundation for the study of gout and related diseases.This article,based on recent researche,summarized the advantages and disadvantages of these animals as models for hyperuricemia study,focusing on uricase-deficient mice and rats.Due to the high similarity between uric acid metabolism in uricase-deficient animals(especially rats)and in humans,and the avoidance of interference from modeling agents,uricase-deficient animals are preferred animals for experimental research on hyperuricemia and gout.Uricase-deficient animals with different levels of serum uric acid will meet the needs of different research requirements if inbreed sublines are successfully established.Uricase-deficient animals is expected to play a more important role in the mechanism research,drug screening and new prevention and treatment strategies development of gout and related metabolic disorders.关键词
高尿酸血症/动物模型/Kunming-DY大鼠/尿酸酶缺失Key words
hyperuricemia/animal model/Kunming-DY rats/uricase deficiency分类
医药卫生引用本文复制引用
李仕雄,段为钢,云宇..高尿酸血症模型动物的研究进展[J].云南民族大学学报（自然科学版）,2025,34(5):545-550,6.基金项目
国家自然科学基金(82260886) （82260886）
云南省中医药联合专项重点项目(202101AZ070001-010). （202101AZ070001-010）
