药食同源杂志2025，Vol.1Issue(1)：68-75,8.
马齿苋水提物对高糖饮食诱导的果蝇模型代谢紊乱的影响
Effects of Machixian(Portulacae Herba)aqueous extract on metabolic disorders in a high-sugar diet-induced Drosophila model
摘要
Abstract
Objective To explore the effects of Machixian(Portulacae Herba)aqueous extract on metabolic disorders in a high-sugar diet-induced Drosophila model.Methods A high-sugar diet was used to induce a metabolic disorder model.The experiment included five groups:a normal group,a model group,and three intervention groups receiving 1％,5％,and 10％aqueous extract of Machixian(Portulacae Herba),each comprising 90 flies.While the normal control group was fed a regular diet,the other groups were fed a high-sugar diet with varying concentrations of Machixian(Portulacae Herba)aqueous extract.After 14 days of cultivation,the survival rate,body weight,pupal volume,eclosion ability,fat droplet size,climbing ability,trehalose content,malondialdehyde(MDA)content,superoxide dismutase(SOD)activity,catalase(CAT)activity,and intestinal permeability(Smurf assay)were measured in each group.Results Compared with the normal control group,the model group of Drosophila exhibited significantly reduced survival rate,body weight,eclosion rate,pupal volume,climbing rate,SOD activity,and CAT activity(P＜0.05,P＜0.01,P＜0.001).Additionally,fat accumulation,intestinal leakage rate,trehalose content,and MDA content significantly increased(P＜0.05,P＜0.001).Compared with the model group,Drosophila treated with different concentrations of Machixian(Portulacae Herba)aqueous extract showed varying degrees of improvement in survival rate,body weight,eclosion rate,pupal volume,climbing rate,SOD activity,and CAT activity(P＜0.05,P＜0.01,P＜0.001).Furthermore,fat accumulation,intestinal leakage rate,trehalose content,and MDA content were significantly reduced(P＜0.05,P＜0.01,P＜0.001).Conclusion The aqueous extract of Machixian(Portulacae Herba)demonstrated significant regulatory effects on high-sugar diet-induced metabolic disorders in Drosophila,effectively improving survival rate,metabolism-related indicators,and oxidative stress status.Its mechanism of action may be associated with enhancing the organism's antioxidant capacity and maintaining the integrity of the intestinal barrier function.关键词
马齿苋/水提物/高糖诱导/果蝇模型/代谢紊乱/抗氧化Key words
Machixian(Portulacae Herba)/aqueous extract/high-sugar diet induction/Drosophila model/metabolic disorder/antioxidation分类
医药卫生引用本文复制引用
张静,周琪,刘志勇,曾梦丽,吴华芳,郭雨昕..马齿苋水提物对高糖饮食诱导的果蝇模型代谢紊乱的影响[J].药食同源杂志,2025,1(1):68-75,8.基金项目
江西中医药大学实验动物科技中心科研孵育班专项课题. （）
