药食同源杂志2025，Vol.1Issue(4)：28-33,6.
纯水体系下葛根素的固液相平衡与溶解热力学分析
Solid-liquid phase equilibrium and dissolution thermodynamic analysis of Gegensu(Puerarin)in a pure water system
摘要
Abstract
Objective To investigate the solubility of Gegensu(Puerarin)in water and its dissolution thermodynamic mechanism.Methods The solubility of Gegensu(Puerarin)was determined within the temperature range of 298-338 K.The experimental data were fitted using the Apelblat equation,polynomial empirical equation,and ideal solution model.Based on the Van't Hoff equation,dissolution thermodynamic parameters were calculated.Results The solubility of Gegensu(Puerarin)increased significantly with increasing temperature(298 K:6.46 mg/mL.338 K:30.06 mg/mL).Among the three models,the polynomial empirical model exhibited the best fit(ARD=2.37%,R2=0.999),followed by the Apelblat equation(ARD=2.43%,R2=0.998).Thermodynamic calculations indicated that the dissolution of Gegensu(Puerarin)is an endothermic,entropy-increasing,non-spontaneous process,with Gibbs free energy(ΔG)decreasing as temperature increased.Conclusion The dissolution behavior of Gegensu(Puerarin)in a pure water system exhibits nonlinear characteristics,and the polynomial empirical equation is the most suitable for describing its dissolution pattern.Increasing temperature enhances the dissolution driving force.This study provides a theoretical basis for the application of Gegensu(Puerarin).关键词
葛根素/溶解度/固液相平衡/溶解热力学Key words
Gegensu(Puerarin)/solubility/solid-liquid phase equilibrium/dissolution thermodynamics分类
医药卫生引用本文复制引用
李琪子怡,刘思仪,黎晓丹,姜玮瑾,周小龙,李运通..纯水体系下葛根素的固液相平衡与溶解热力学分析[J].药食同源杂志,2025,1(4):28-33,6.基金项目
湖南省大学生创新创业训练计划项目(S202310531045) （S202310531045）
国家级大学生创新训练计划项目(S202410531001) （S202410531001）
吉首大学2024年度本科生校级科研项目(005). （005）
