临床研究2025，Vol.33Issue(10)：13-17,5.DOI:10.12385/j.issn.2096-1278(2025)10-0013-05
围手术期血清hs-CRP、IL-10、IFN-γ与冠心病患者PCI术后发生心肌损伤的相关性分析
Correlation Analysis of Perioperative Serum hs-CRP,IL-10,and IFN-γ with Myocardial Injury after Percutaneous Coronary Intervention in Patients with Coronary Heart Disease
摘要
Abstract
Objective To investigate the correlation between perioperative serum high-sensitivity C-reactive protein(hs-CRP),interleukin-10(IL-10),interferon-γ(IFN-γ),and myocardial injury after percutaneous coronary intervention(PCI)in patients with coronary heart disease(CHD).Methods A total of 220 CHD patients who underwent PCI at the Affiliated Hospital of Xinyang Vocational and Technical College from January 2020 to December 2024 were enrolled.According to the occurrence of myocardial injury after PCI,patients were divided into an injury group(n=106)and a non-injury group(n=114).Clinical data and serum biochemical indicators were compared between the two groups.Risk factors for myocardial injury after PCI were analyzed using multivariate logistic regression.Receiver operating characteristic(ROC)curves were plotted,and the area under the curve(AUC)was calculated to evaluate the diagnostic value of serum hs-CRP,IL-10,and IFN-γ for predicting myocardial injury after PCI.Results Among the 220 CHD patients,106(48.18%)developed myocardial injury after PCI.The proportions of patients aged＞60 years,with prolonged operative time,intraoperative no-reflow or slow flow,multivessel coronary artery disease,≥2 stents implanted,total stent length≥35 mm,and higher Gensini scores were significantly higher in the injury group than in the non-injury group(P＜0.05).One day before PCI,there were no significant differences in baseline levels of serum hs-CRP,IL-10,IFN-γ,HDL-C,LDL-C,and Apo B between the two groups(P＞0.05).One day after PCI,the levels of hs-CRP,IFN-γ,and Apo B in the injury group were higher than those in the non-injury group,while the IL-10 level was lower(P＜0.05).Multivariate logistic regression analysis showed that age(OR=2.298,95%CI:1.135～4.651),operative time(OR=2.524,95%CI:1.148～5.547),intraoperative no-reflow/slow flow(OR=2.815,95%CI:1.327～5.971),number of diseased coronary vessels(OR=2.375,95%CI:1.483～3.804),Gensini score(OR=2.340,95%CI:1.359～4.029),number of implanted stents(OR=2.612,95%CI:1.401～4.869),total stent length(OR=2.399,95%CI:1.327～4.337),Postoperative hs-CRP(OR=3.445,95%CI:1.620～7.325),postoperative IL-10(OR=0.600,95%CI:0.492～0.703),postoperative IFN-γ(OR=2.784,95%CI:1.335～5.800),and postoperative Apo B(OR=2.375,95%CI:1.074～5.253)were all identified as influencing factors for myocardial injury in patients with coronary heart disease after PCI.ROC curve analysis demonstrated that the combined detection of serum hs-CRP,IL-10,and IFN-γ yielded the highest diagnostic value(AUC=0.832),with sensitivity of 78.67%and specificity of 89.46%.Conclusion Combined detection of postoperative serum hs-CRP,IL-10,and IFN-γ has high diagnostic value for myocardial injury after PCI in patients with CHD,and its diagnostic efficacy is superior to that of a single indicator.关键词
冠心病/经皮冠状动脉介入治疗/心肌损伤/超敏C-反应蛋白/白细胞介素-10/γ-干扰素Key words
coronary heart disease/percutaneous coronary intervention/myocardial injury/high-sensitivity C-reactive protein/interleukin-10/interferon-γ分类
医药卫生引用本文复制引用
李鸿杰,黄晶,王璐..围手术期血清hs-CRP、IL-10、IFN-γ与冠心病患者PCI术后发生心肌损伤的相关性分析[J].临床研究,2025,33(10):13-17,5.基金项目
信阳市软科学项目(20230041) （20230041）
