湖北医药学院学报2025，Vol.44Issue(5)：525-531,7.DOI:10.13819/j.issn.2096-708X.2025.05.002
捻转血矛线虫环鸟苷酸信号通路重要基因功能预测
Functions of Key Genes in the Cyclic Guanosine Monophosphate(cGMP)Signaling Pathway of Haemonchus cont-ortus:A Prediction
摘要
Abstract
Objective To predict the functions of key genes in the cyclic guanosine monophosphate(cGMP)signaling path-way of Haemonchus contortus.Methods Gene sequences of the cGMP signaling pathway in Caenorhabditis elegans were used to identify corresponding genes in H.contortus through sequence alignment,and gene structure diagrams were con-structed.Phylogenetic trees were generated using MEGA to analyze the evolutionary relationships of related proteins.Func-tional domains were predicted by comparing the protein sequences of H.contortus with homologous sequences from other species.Results Four genes involved in the cGMP signaling pathway of H.contortus were identified:Hc-daf-11,Hc-gpa-2,Hc-gpa-3,and Hc-tax-2.Corresponding proteins contained highly conserved functional domains and exhibited evolu-tionary relationships with proteins from other nematodes.Conclusion This study provides preliminary insights into the struc-ture and function of key genes in the cGMP signaling pathway of H.contortus in regulating growth and development,laying a foundation for further research on antinematodal drugs.关键词
捻转血矛线虫/环鸟苷酸信号通路/生物信息学分析/功能预测Key words
Haemonchus contortus/Cyclic guanosine monophosphate(cGMP)signaling pathway/Bioinformatics analysis/Function prediction引用本文复制引用
阮丹力,谢蕊洁,刘静,张蕙,董晶鑫,陈元奇,何莉..捻转血矛线虫环鸟苷酸信号通路重要基因功能预测[J].湖北医药学院学报,2025,44(5):525-531,7.基金项目
湖北医药学院人才启动金(2019QDJZR03) （2019QDJZR03）
武当特色中药研究湖北省重点实验室(湖北医药学院)开放课题(WDCM2024019) （湖北医药学院）
