湖北医药学院学报2025，Vol.44Issue(5)：539-543,后插2,6.DOI:10.13819/j.issn.2096-708X.2025.05.004
连翘苷缓解高尿酸血症肾病的作用研究
Effect of Phillyrin on Alleviating Hyperuricemic Nephropathy
摘要
Abstract
Objective To investigate the effect of phillyrin on improving hyperuricemic nephropathy.Methods Hyperurice-mia(HUA)mouse model was established by intraperitoneal injection of 300 mg/kg hypoxanthine combined with 300 mg/kg potassium oxonate for 7 days.Forty-two male ICR mice were randomly divided into six groups:a control group,a phill-yrin group(120 mg/kg),a HUA group,a febuxostat group(10 mg/kg),a low-dose phillyrin-HUA group(40 mg/kg),and a high-dose phillyrin-HUA group(120 mg/kg).Serum samples from the mice were tested for uric acid,creatinine,urea nitrogen,and nitric oxide(NO)using a kit method.Gross morphological changes were observed and renal index were calculated.Pathological changes in kidney tissues were analyzed by hematoxylin-eosin(HE)staining.Results The kid-neys in the model group exhibited pathological changes such as significantly increased serum uric acid,tubular dilation,and glomerular atrophy,along with a significantly elevated renal index,creatinine,serum uric acid,and urea nitrogen,and markedly decreased serum NO compared with the control group.Following intervention with phillyrin,there was a distinct decrease in serum uric acid,and renal function and histological morphology revealed varying degrees of recovery.Pathologi-cal damage in renal tissue was alleviated,and serum NO markedly increased.Conclusion Phillyrin exhibits a pronounced hypouricemic effect and remarkably alleviates renal damage in HUA mice induced by hypoxanthine combined with potassium oxonate,possibly through the improvement of endothelial dysfunction.关键词
连翘苷/高尿酸血症肾病/降尿酸/肾保护Key words
Phillyrin/Hyperuricemia nephropathy/Uric acid reduction/Renal protection引用本文复制引用
张艳,桂利利,余惠凡,刘丽,江英,李飞,罗寒..连翘苷缓解高尿酸血症肾病的作用研究[J].湖北医药学院学报,2025,44(5):539-543,后插2,6.基金项目
湖北省自然科学基金青年B类项目(JCZRQN202500430) （JCZRQN202500430）
湖北医药学院"十四五"湖北省高等学校优势特色学科群(生物与医药)项目(2024BMXKQT1) （生物与医药）
