现代畜牧科技Issue(10)：22-25,4.DOI:10.19369/j.cnki.2095-9737.2025.10.006
穿心莲内酯与恩诺沙星联合用药对禽源大肠杆菌的体外抑菌试验
In Vitro Antibacterial Effect of Combination Therapy of Andrographolide and Enrofloxacin on Avian Escherichia coli
摘要
Abstract
To investigate the in vitro antibacterial effect of the combination of Chuanxinlian lactone and enrofloxacin on avian resistant Escherichia coli.Select the non repetitive drug-resistant Escherichia coli MRE1～MRE13 and quality control bacterium ATCC25922 isolated and identified in our laboratory,and use the micro broth dilution method to determine the MIC of Chuanxinlian lactone and enrofloxacin on the test bacteria when used alone and in combination,and calculate the FIC of the combination therapy.The results showed that among the 14 experimental strains,11 exhibited good synergistic or additive effects(FIC≤1),while the sterile strains showed antagonistic effects.The experiment showed that a certain concentration of andrographolide combined with enrofloxacin has a strong synergistic effect on the in vitro inhibition of drug-resistant Escherichia coli.Proper combination of the two can reduce the development of enrofloxacin resistance.关键词
穿心莲/恩诺沙星/大肠杆菌/联合用药/耐药性Key words
common andrographis herb/Enrofloxacin/Escherichia coli/drug combination/drug tolerance分类
农业科技引用本文复制引用
李晴,赵俊楠,宿广栋,魏秀丽,刘少宁,张琦,冯鑫磊,朱良智,布岩林,王奕澄,闫传奇,范明月..穿心莲内酯与恩诺沙星联合用药对禽源大肠杆菌的体外抑菌试验[J].现代畜牧科技,2025,(10):22-25,4.基金项目
泰山产业创新领军人才专项资助(TSCX202211023) （TSCX202211023）
山东省重点研发计划:蛋鸡福利化健康养殖与用药安全关键技术研究(2022CXPT022) （2022CXPT022）
