中国癌症杂志2025，Vol.35Issue(9)：874-883,10.DOI:10.19401/j.cnki.1007-3639.2025.09.008
胃癌领域抗肿瘤药物相关间质性肺病/肺炎的研究进展及展望
Research progress and future perspectives of anticancer drug-induced interstitial lung disease/pneumonia in gastric cancer
摘要
Abstract
Gastric cancer presents a high incidence rate and substantial disease burden,posing significant therapeutic challenges.Recent advances have yielded significant benefits for gastric cancer patients through novel anti-tumor agents,including immune checkpoint inhibitor(ICI),human epidermal growth factor receptor 2(HER2)-targeted therapies,and claudin 18.2(CLDN18.2)-directed agents.Both monotherapy and various combination regimens demonstrate considerable promise in gastric cancer treatment.However,a critical safety concern potentially limiting patient benefit is drug-induced interstitial lung disease(ILD)/pneumonitis,particularly associated with ICI and antibody-drug conjugate(ADC).The risk and underlying mechanisms of ILD vary considerably across different anti-tumor drug classes,and its often insidious onset makes early detection difficult.Therefore,a deep understanding of the distinct ILD risks and mechanisms associated with different agents,coupled with rational,individualized drug monitoring and patient management,is paramount.This review systematically analyzes the incidence rates,clinical characteristics,and risk factors associated with ILD/pneumonitis reported in recent clinical trials of anti-tumor therapies for gastric cancer.It aimed to elucidate the risk stratification and mechanistic differences between drug classes,thereby enhancing clinical awareness and ultimately helping to maximize clinical outcomes for gastric cancer patients.关键词
胃癌/抗肿瘤药物/间质性肺病/肺炎/进展Key words
Gastric cancer/Anticancer drug/Interstitial lung disease/Pneumonitis/Progress分类
医药卫生引用本文复制引用
郭晓玉,曲秀娟..胃癌领域抗肿瘤药物相关间质性肺病/肺炎的研究进展及展望[J].中国癌症杂志,2025,35(9):874-883,10.基金项目
科技创新2030-"癌症、心脑血管、呼吸和代谢性疾病防治研究"重大项目专项(2023ZD0501500). Noncommunicable Chronic Diseases-National Science and Technology Major Project 2023ZD0501500). （2023ZD0501500）
