中国当代儿科杂志2025，Vol.27Issue(10)：1227-1232,6.DOI:10.7499/j.issn.1008-8830.2504006
复方磺胺甲(口恶)唑治疗儿童百日咳诱发皮疹的临床特征分析
Clinical characteristics of trimethoprim-sulfamethoxazole-induced rash during treatment of pertussis in children
摘要
Abstract
Objective To study the clinical characteristics of rashes induced by trimethoprim-sulfamethoxazole(TMP-SMZ)in children treated for pertussis and to inform safe medication practices.Methods A retrospective analysis was conducted on 238 children diagnosed with pertussis and treated with TMP-SMZ at Wuhu First People's Hospital from January to August 2024.The incidence and clinical features of rashes were summarized.Results Of 238 children,34(14.3%)developed rashes;19(55.9%)were boys,and the 5 to<10-year age group accounted for the highest proportion(70.6%,24/34).A history of allergic disease was present in 50.0%(17/34).Rashes typically appeared on or after day 7 of therapy(82%,28/34)and were predominantly erythematous or maculopapular eruptions(97%,33/34);71%(24/34)were pruritic.Fever occurred in 56%(19/34);among those who were tested for respiratory viruses,77%(10/13)were positive for viruses such as rhinovirus and adenovirus.After discontinuation of TMP-SMZ,rashes resolved within 3 days in 97%(33/34)of patients(41%within 1 day;56%within more than 1 but within 3 days).There was no significant difference in rash incidence between photoprotection and non-photoprotection groups(P>0.05).Conclusions TMP-SMZ for pertussis can induce rashes,particularly in children aged 5 to<10 years.The eruption is usually a pruritic erythematous or maculopapular rash,with over half of cases accompanied by fever and frequent concomitant viral infections.Most rashes resolve within 3 days after drug withdrawal.The potential association between the rash and sun exposure warrants further investigation.关键词
百日咳/复方磺胺甲(口恶)唑/皮疹/儿童Key words
Pertussis/Trimethoprim-sulfamethoxazole/Rash/Child引用本文复制引用
汪丙松,姚开虎,张贤溢,吴菁,应斐,董立民..复方磺胺甲(口恶)唑治疗儿童百日咳诱发皮疹的临床特征分析[J].中国当代儿科杂志,2025,27(10):1227-1232,6.基金项目
北京重大呼吸道传染病研究中心项目(BJRID2025-008) （BJRID2025-008）
北京市卫生健康委员会改革与发展项目(EYGF-WSW-04) （EYGF-WSW-04）
芜湖市科技局资助项目(2020ms3-18) （2020ms3-18）
芜湖市卫生健康委重点科研项目(WHWJ2022z003). （WHWJ2022z003）
