中国动物检疫2025，Vol.42Issue(10)：19-27,9.DOI:10.3969/j.issn.1005-944X.2025.10.004
小反刍兽疫病毒的流行演化
The Epidemiological Evolution of PPRV
摘要
Abstract
Peste des petits ruminants(PPR)is a major animal disease spreading across boundaries,posing a serious threat to the development of cattle and sheep industries in Asian and African regions.Here,genetic evolutionary relationships of virus strains in different regions were sorted out through systematically analyzing the general characteristics,genetic typing,global transmission and evolution history,mutation mechanisms and influencing factors of the virus,and in combination with methods such as molecular epidemiology and phylogenetic analysis.The virus had gradually spread to other parts of Africa,as well as Asia and Europe since it was firstly reported in Cote d'Ivoire,and evolved into four lineages(Ⅰ-Ⅳ),including lineage Ⅳ that was dominant in the world due to its strong adaptability and widespread transmission;and all the prevalent strains in China belonged to lineage Ⅳ,although there were genetic differences in different regions.The virus spread and mutated with obvious spatiotemporal characteristics,which was influenced by various factors,leading to current challenges in PPR control,including lineage expansion and strain variation.It was thereby recommended to approach the goal of global eradication by improving monitoring,vaccine development and cross-border cooperation.关键词
小反刍兽疫/系统进化分析/同源性/遗传变异Key words
PPR/phylogenetic analysis/homology/genetic variation分类
农业科技引用本文复制引用
李慧聪,徐蛟,王清华,王英丽,包静月..小反刍兽疫病毒的流行演化[J].中国动物检疫,2025,42(10):19-27,9.基金项目
"十四五"国家重点研发计划项目(2022YFD1800500) （2022YFD1800500）
