中国动物检疫2025，Vol.42Issue(10)：82-90,9.DOI:10.3969/j.issn.1005-944X.2025.10.013
PRRSV nsp4蛋白的结构和功能研究进展
Advances in the Structure and Functions of PRRSV nsp4 Protein
摘要
Abstract
At least 14 nonstructural proteins(nsp)might be encoded by the genome of porcine reproductive and respiratory syndrome virus(PRRSV),especially nsp4 protein that is with the activity of 3C-like serine protease(3CLSP)and plays a critical role in viral replication,inhibition of host innate immune responses and induction of host cell apoptosis.Here,the latest advances in the nsp4 protein were systematically reviewed,with a priority on its structural characteristics and recent findings in areas such as inhibiting host innate immunity and promoting viral replication,aiming to provide innovative insights for the prevention and control of porcine reproductive and respiratory syndrome(PRRS),as well as theoretical references for future development of novel vaccines and therapeutic drugs.关键词
猪繁殖和呼吸综合征病毒/nsp4蛋白/3C样丝氨酸蛋白酶/宿主免疫/病毒复制Key words
PRRSV/nsp 4 protein/3CLSP/host immunity/virus replication分类
农业科技引用本文复制引用
李兴玉,于吉锋,李金海,康玮笠,毛从剑,康润敏..PRRSV nsp4蛋白的结构和功能研究进展[J].中国动物检疫,2025,42(10):82-90,9.基金项目
四川省生猪创新团队项目(sccxtd-2024-08-04) （sccxtd-2024-08-04）
四川省财政运行专项(SASA2025CZYX006) （SASA2025CZYX006）
四川省区域创新合作项目(2024YFHZ0110,2025YFHZ0307) （2024YFHZ0110,2025YFHZ0307）
四川省重点研发项目(2024YFNH0017) （2024YFNH0017）
四川省衔接推进乡村振兴科技专项(2024ZHXC0005) （2024ZHXC0005）
