中国畜牧兽医2025，Vol.52Issue(10)：4663-4676,14.DOI:10.16431/j.cnki.1671-7236.2025.10.012
霉菌毒素对母猪生殖系统的损伤机制研究进展
Research Progress on the Damage Mechanism of Mycotoxins on the Reproductive System of Sows
摘要
Abstract
As toxic fungal secondary metabolites,mycotoxins are ubiquitously present in agroecosystems,with their contamination in crops and feed materials has emerged as a global threat to food safety.These compounds exhibit well-characterized hepatotoxic,carcinogenic,teratogenic,immunotoxic,and neurotoxic properties,posing substantial risks to human and animal health.Mycotoxins severely impair the physiological homeostasis of reproductive system in sows through multi-pathway disruptions,leading to infertility,abortions and other reproductive disorders.Therefore,elucidating the mechanisms underlying their reproductive toxicity is critical for mitigating breeding-associated risks and developing targeted prevention strategies.This review systematically summarizes the classification of major mycotoxins and their contamination profiles in Chinese raw materials and feed.Mycotoxins enter sows through contaminated feed,inducing multi-level impairments including ovarian dysfunction,uterine developmental anomalies,and dysregulation of reproductive endocrine homeostasis.The review provides a molecular-level analysis of mycotoxin-induced damage mechanisms associated with follicular developmental disorders,oocyte maturation defects,and regulation of granulosa cell apoptosis through specific signaling pathways.Regarding mitigation technologies,the article integrates diversified detoxification strategies including physical adsorption,chemical degradation,and microbial biotransformation,and proposes a systematic framework.By elucidating the reproductive toxicological effects of mycotoxins and their intervention nodes from multi-faceted analysis,so as to provide a critical theoretical foundation for establishing a comprehensive prevention system against sow reproductive disorders.关键词
霉菌毒素/母猪/繁殖障碍/毒性作用/防控策略Key words
mycotoxins/sows/reproductive disorders/toxicity/prophylactic strategies分类
农业科技引用本文复制引用
谢煜鹏,邹红,张树敏,孙武胜..霉菌毒素对母猪生殖系统的损伤机制研究进展[J].中国畜牧兽医,2025,52(10):4663-4676,14.基金项目
吉林省教育厅科学技术研究项目(JJKH20240466KJ) （JJKH20240466KJ）
吉林农业大学优秀博士科研启动经费(201020846) （201020846）
