内科2025，Vol.20Issue(4)：394-398,5.DOI:10.16121/j.cnki.cn45-1347/r.2025.04.08
高剂量二联疗法与含铋剂四联疗法根除幽门螺杆菌的临床疗效及安全性比较
Comparison of clinical efficacy and safety between high-dose dual therapy and bismuth-containing quadruple therapy for Helicobacter pylori eradication
王伟 1张玲 1张正坤 1姚建华 1夏铭 1郭文杰2
作者信息
- 1. 甘肃省酒泉市人民医院,酒泉市 735000
- 2. 成都大学基础医学院,四川省 成都市 610000
- 折叠
摘要
Abstract
Objective To compare the clinical efficacy and safety of high-dose dual therapy and bismuth-containing quadruple therapy for Helicobacter pylori(H.pylori)eradication.Methods A total of 100 patients with H.pylori infection admitted to Jiuquan People's Hospital of Gansu Province from February 2019 to October 2020 were selected as the research objects,and they were divided into a dual therapy group(n=50)or a quadruple therapy group(n=50)using the random number table method.The dual therapy group received high-dose dual therapy(omeprazole+amoxicillin),while the quadruple therapy group received bismuth-containing quadruple therapy(omeprazole+bismuth potassium citrate+clarithromycin+amoxicillin).The H.pylori eradication rate,medication adherence,total incidence of adverse drug reactions,and drug tolerance were compared between the two groups.Results There was no statistically significant difference in the H.pylori eradication rate between high-dose dual therapy and bismuth-containing quadruple therapy:intention to treat analysis showed that the eradication rates of the dual therapy group and the quadruple therapy group were 86.00%(43/50)and 82.00%(41/50),respectively(χ²=0.298,P=0.585);per protocol analysis showed that the eradication rates were 93.48%(43/46)and 91.11%(41/45),respectively(tested by Fisher's exact probability method,P=1.000).After 14 days of treatment,the score of the Chinese version of the 4-item Morisky Medication Adherence Scale in the dual therapy group was higher than that in the quadruple therapy group(P<0.05).During the treatment period,the total incidence of adverse drug reactions in the dual therapy group was lower than that in the quadruple therapy group,and the drug tolerance was better than that in the quadruple therapy group(all P<0.05).Conclusion There is no statistically significant difference in the efficacy for H.pylori eradication between the high-dose dual therapy and the bismuth-containing quadruple therapy,while the former has higher medication adherence,fewer adverse drug reactions,and better drug tolerance in patients.关键词
高剂量二联疗法/含铋剂四联疗法/幽门螺杆菌/疗效/安全性Key words
High-dose dual therapy/Bismuth-containing quadruple therapy/Helicobacter pylori/Efficacy/Safety分类
医药卫生引用本文复制引用
王伟,张玲,张正坤,姚建华,夏铭,郭文杰..高剂量二联疗法与含铋剂四联疗法根除幽门螺杆菌的临床疗效及安全性比较[J].内科,2025,20(4):394-398,5.
