中国医药科学2025，Vol.15Issue(18)：29-32,66,5.DOI:10.20116/j.issn2095-0616.2025.18.05
基于"第二病因"之"瘀"辨治燥痹的理论与实践研究
Theoretical and practical study on managing sjogren syndrome based on the"Stasis"(Yu)Component of the"Second Etiology"theory
摘要
Abstract
Sjögren's syndrome(SS)is a chronic inflammatory autoimmune disorder characterized by lymphocytic infiltration of exocrine glands,with core manifestations of xerostomia,xerophthalmia,parotid enlargement,and systemic involvement.Due to complex etiology and pathogenesis,neither Western nor traditional Chinese medicine(TCM)has established a fully unified framework.The"Second Etiology"theory provides a novel perspective for SS pathological evolution,positing that"toxicity"(Du)and"stasis"(Yu)are pivotal drivers of progression subsequent to initial mechanisms."Stasis"manifests as hypercoagulability,microcirculatory impairment,and glandular fibrosis,directly impeding body fluid(Jin Ye)distribution and exacerbating sicca symptoms and systemic damage.This article focuses on the central role of"stasis"as a second etiology,systematically reviewing literature to analyze its formation mechanisms,pathological effects,and rationale as a therapeutic target in SS.By examining the evidence supporting the multi-dimensional intervention of"Activating Blood Circulation and Resolving Stasis"(Huo Xue Hua Yu Fa)-aiming to"eliminate stasis to regenerate tissues and unblock collaterals to distribute fluids"(Qu Yu Sheng Xin,Tong Luo Bu Jin)-in SS management,this review substantiates the theoretical validity of"stasis"as a second etiology.It aims to provide integrated theoretical foundation and practical direction for applying this approach within SS treatment,facilitating optimization of integrated Chinese-Western medical therapies.关键词
干燥综合征/病因学说/病机/活血化瘀/辨证论治Key words
Sjögren's syndrome/Etiology/Pathogenesis/Promoting blood circulation for removing blood stasis/Treatment based on syndrome differentiation分类
医药卫生引用本文复制引用
于宛仪,张杰..基于"第二病因"之"瘀"辨治燥痹的理论与实践研究[J].中国医药科学,2025,15(18):29-32,66,5.基金项目
"兴辽英才计划"医学名家项目(YXMJ-MZY-12). （YXMJ-MZY-12）
