中国医药科学2025，Vol.15Issue(18)：112-116,5.DOI:10.20116/j.issn2095-0616.2025.18.22
经鼻高流量湿化氧疗在缺血性脑卒中患者中应用效果的meta分析
Meta-analysis of the application effect of high-flow oxygen through nasal cannula in patients with ischemic stroke
摘要
Abstract
Objective To conduct a meta-analysis on the application effect of high-flow oxygen through nasal cannula(HFNC)in patients with ischemic stroke.Methods Randomized controlled trials(RCTs)and quasi trials on the application of HFNC in ischemic stroke patients were retrieved from databases such as CNKI,Wanfang,VIP,PubMed,Web of Science,Embase,and Cochrane Library,with the search period spanning from the inception of each database to December 31,2023.Additionally,reference lists of included studies were manually searched.Two researchers independently conducted literature screening,data extraction,and quality evaluation,using RevMan 5.3 software for data analysis.The combined effect statistic was represented by standardized mean difference(SMD),relative risk(RR),and 95%confidence interval(CI).Results A total of 8 articles and 851 patients were ultimately included in the study.1 A-level literature and 7 B-level literature.The meta-analysis results showed that patients in the HFNC group and the control group had differences in arterial oxygen partial pressure(PaO2)(SMD=1.29,95%CI[0.69,1.89],P<0.0001),arterial oxygen saturation(SaO2)(SMD=0.97,95%CI[0.13,1.81],P=0.02),oxygenation index(SMD=0.62,95%CI[0.41,0.82],P<0.000 01),respiratory rate(SMD=-1.21,95%CI[-1.77,-0.65],P<0.0001),heart rate(SMD=-1.11,95%CI[-1.85,-0.37],P=0.003),tracheal intubation rate(RR=0.49,95%CI[0.35,0.685],P<0.0001)and ICU length of stay(SMD=-2.85,95%CI[-4.50,-1.20],P=0.0007).There was no statistically significant difference in arterial partial pressure of carbon dioxide(PaCO2)(SMD=-0.60,95%CI[-1.29,0.08],P=0.08),and mortality rate(RR=0.97,95%CI[0.50,1.85],P=0.92).Conclusion HFNC can increase patients'PaO2 and SaO2,improve oxygenation index,stabilize respiratory rate and heart rate,shorten ICU stay,and reduce tracheal intubation.However,the quality of the included studies is moderate,and more high-quality,multicenter RCTs are still needed for validation in the future.关键词
经鼻高流量湿化氧疗/常规氧疗/脑卒中/随机对照试验/meta分析Key words
High-flow oxygen through nasal cannula/Conventional oxygen therapy/Stroke/Randomized controlled trial/Meta-analysis分类
医药卫生引用本文复制引用
韩明月,刘雪芳,王桂华,苗凤茹..经鼻高流量湿化氧疗在缺血性脑卒中患者中应用效果的meta分析[J].中国医药科学,2025,15(18):112-116,5.基金项目
北京市海淀区卫生健康发展科研培育计划(HP2022-98-507003). （HP2022-98-507003）
