中国卒中杂志2025，Vol.20Issue(9)：1087-1096,10.DOI:10.3969/j.issn.1673-5765.2025.09.003
基于MI-SSVEP的脑机接口辅助康复训练对卒中患者上肢运动功能的影响
Effects of MI-SSVEP-Based Brain-Computer Interface-Assisted Rehabilitation Training on Upper Limb Motor Function in Stroke Patients
摘要
Abstract
Objective To evaluate the rehabilitation effects of brain-computer interface(BCI)-assisted rehabilitation training based on motor imagery(MI)and steady-state visual evoked potential(SSVEP)on upper limb motor function and activities of daily living in stroke patients. Methods This study was a prospective,single-center,randomized controlled trial,which enrolled stroke patients with hemiplegia within 2 weeks to 12 months after onset.These patients were randomly divided into an experimental group and a control group.Both groups received conventional rehabilitation training,including physical therapy,occupational therapy with each training lasting 30 minutes,5 days per week,for 2 consecutive weeks,totaling 10 sessions.On the basis of conventional rehabilitation training,the experimental group additionally received 10 sessions of BCI-assisted rehabilitation training(each session lasting 45 minutes,5 days per week,for 2 consecutive weeks,totaling 10 sessions).A dual-modal closed-loop system based on MI and SSVEP was used to control an exoskeleton manipulator for performing grasping tasks.The primary outcome measures were the Fugl-Meyer motor assessment-upper extremity(FMA-UE)to evaluate upper limb motor function and the modified Barthel index(mBI)to evaluate activities of daily living.The secondary outcome measures included the modified Ashworth scale(MAS)for evaluating muscle tone,the Hamilton anxiety scale(HAMA)for evaluating anxiety status,and the Hamilton depression scale(HAMD)for evaluating depressive status.All patients completed the assessments before intervention,after intervention,and 2 weeks after the end of intervention(follow-up period). Results A total of 36 stroke patients with hemiplegia were enrolled,with 18 patients in the experimental group and 18 in the control group.There were no statistically significant differences in baseline data and scale assessment results between the two groups.Analysis of primary outcome measures showed that both FMA-UE scores and mBI scores of the two groups had significant time effects(FMA-UE scores:F=58.519,P<0.001;mBI scores:F=129.935,P<0.001)and time×group interaction effects(FMA-UE scores:F=19.551,P<0.001;mBI scores:F=15.661,P<0.001).The scores of both groups showed an increasing trend with the extension of time.Specifically,the score improvements of the experimental group were better than those of the control group after intervention(FMA-UE scores:P=0.049;mBI scores:P=0.035)and during the follow-up period(FMA-UE scores:P=0.005;mBI scores:P=0.002).Analysis of secondary outcome measures showed that after intervention,the HAMA scores and HAMD scores of both groups improved,and the improvement trend in the experimental group was more obvious.However,there were no statistically significant differences in HAMA scores,HAMD scores,and MAS grades between the two groups.The BCI feedback accuracy of the experimental group increased from(65.97±14.70)％before intervention to(76.34±12.16)％after intervention,and the difference was statistically significant(P=0.008). Conclusions For stroke patients with hemiplegia,MI-SSVEP-based BCI-assisted rehabilitation training combined with conventional rehabilitation training can effectively improve their upper limb motor function and activities of daily living.关键词
卒中/脑机接口/上肢运动功能/康复Key words
Stroke/Brain-computer interface/Upper limb motor function/Rehabilitation分类
医药卫生引用本文复制引用
夏小茜,刘丽旭,康晓宇,贾凌云,王倩惠,张琳瑶,张若晴,王艺铮,吴晓莉,陈小刚..基于MI-SSVEP的脑机接口辅助康复训练对卒中患者上肢运动功能的影响[J].中国卒中杂志,2025,20(9):1087-1096,10.基金项目
国家重点研发计划(2022YFC3602802)中央级公益性科研院所基本科研业务费专项资金(CRSI2025ZH-5) （2022YFC3602802）
