中国卒中杂志2025，Vol.20Issue(9)：1137-1145,9.DOI:10.3969/j.issn.1673-5765.2025.09.009
头颈部动脉支架植入围手术期患者血清NETs标志物的动态变化
Dynamic Changes in Serum NETs Markers during the Perioperative Period in Patients Undergoing Head and Neck Arterial Stent Implantation
摘要
Abstract
Objective To explore the dynamic changes over time in serum levels of neutrophil extracellular traps(NETs)markers—citrullinated histone 3(cit-H3)and myeloperoxidase(MPO)—after head and neck arterial stent implantation. Methods Patients with atherosclerotic stenosis of the head and neck arteries who underwent stent implantation were prospectively and consecutively enrolled.Venous blood samples were collected from the patients within 24 hours of fasting before surgery,and at 6,12,24,and 48 hours after surgery to measure serum cit-H3 and MPO levels.One-way repeated measures analysis of variance with Greenhouse-Geisser correction was used to compare the dynamic changes in serum cit-H3 and MPO levels across different perioperative time points.Subgroup analyses of the changes in serum cit-H3 and MPO levels were conducted based on stent implantation site(intracranial vs. extracranial),number of stents implanted(1 vs. 2),whether the responsible vessel had symptomatic stenosis,and whether cerebral infarction was in the acute phase(disease duration≤14 days)at the time of surgery. Results A total of 48 patients were enrolled in this study with a mean age of(61.8±8.4)years,including 42 males(87.5％).Among all patients,the serum cit-H3 levels before surgery and at 6,12,24,and 48 hours after surgery were(54.50±6.48)ng/mL,(56.73±6.50)ng/mL,(71.27±7.35)ng/mL,(53.53±17.35)ng/mL,and(52.22±5.45)ng/mL,respectively.The serum MPO levels at the corresponding time points were(25.45±6.67)ng/mL,(26.29±6.75)ng/mL,(28.28±7.68)ng/mL,(31.55±9.09)ng/mL,and(28.68±7.61)ng/mL,respectively.Both markers showed a trend of increasing first and then decreasing,with statistically significant overall differences(P=0.002 for cit-H3;P=0.022 for MPO).In the extracranial and intracranial stent subgroups,the single and double stent subgroups,the symptomatic stenosis subgroup,and the non-acute phase subgroup,the serum cit-H3 levels peaked at 12 hours after surgery.The serum MPO levels peaked at 12 hours after surgery in the intracranial stent subgroup.However,in the double stent subgroup,the symptomatic stenosis subgroup,and the non-acute phase subgroup,the serum MPO levels peaked at 24 hours after surgery. Conclusions Within 48 hours after head and neck artery stent implantation,the serum levels of NETs markers cit-H3 and MPO showed an initial increase followed by a gradual return to preoperative levels.This trend was more pronounced in patients with symptomatic arterial stenosis.关键词
头颈部动脉支架植入/髓过氧化物酶/瓜氨酸化组蛋白3Key words
Head and neck artery stent implantation/Myeloperoxidase/Citrullinated histone 3分类
医药卫生引用本文复制引用
李涛,王何莹,张磊,卜宁,李雯娴,樊洪,张桂莲,吴宇伦,王小雅,李也,陆家梁,路子微,党美娟,赵莉莉,坚雅婷..头颈部动脉支架植入围手术期患者血清NETs标志物的动态变化[J].中国卒中杂志,2025,20(9):1137-1145,9.基金项目
四大慢病重大专项(2023ZD0505400)国家自然科学基金(81971116) （2023ZD0505400）
