中国现代医生2025，Vol.63Issue(27)：19-22,92,5.DOI:10.3969/j.issn.1673-9701.2025.27.004
凝血指标和纤溶指标在急性髓系白血病患者治疗中的水平变化及预测价值
Study on the level changes and predictive value of coagulation and fibrinolytic indices in the treatment of patients with acute myeloid leukemia
摘要
Abstract
Objective To investigate the changes in the levels of D-dimer(D-D),fibrin degradation product(FDP),thrombomodulin(TM),thrombin-antithrombin complex(TAT),tissue plasminogen activator-plasminogen activator inhibitor-1 complex(t-PAIC),and plasmin-alpha 2 plasmin inhibitor complex(PIC)during the treatment of patients with acute myeloid leukemia(AML)and their predictive value for efficacy and prognosis.Methods Thirty-one AML patients initially diagnosed at Guidong People's Hospital of Guangxi Zhuang Autonomous Region from January 2022 to December 2024 were collected as observation group,and 34 healthy medical checkupers were selected as control group.The changes in the levels of the indicators between two groups as well as before,during and after the treatment of observation group were compared,and observation group was divided into remission group and non-remission group according to the efficacy criteria,and the levels of the indicators between two groups were further compared.Risk factors for the efficacy and prognosis of AML patients were analyzed by using Logistic regression analysis.Results Before treatment,the levels of prothrombin time(PT),activated partial thromboplastin time(APTT),D-D,FDP,t-PAIC,PIC,TM and TAT in observation group were significantly higher than those in control group(P＜0.05),whereas there was no significant difference in fibrinogen(Fib)compared with control group(P＞0.05).During the treatment,the levels of t-PAIC and TM in observation group were higher than those before treatment(P＜0.05);After treatment,the levels of PT,D-D,FDP,PIC and TAT in observation group were significantly lower than those before treatment(P＜0.05).After treatment,the levels of PT,D-D,FDP,t-PAIC,PIC,TM and TAT were all lower than those during treatment(P＜0.05).The D-D,FDP,t-PAIC,PIC,TAT and TM levels in non-remission group were all higher than those in remission group,with the t-PAIC and TM levels showing statistical significance(P＜0.05).Binary Logistic regression analysis showed that t-PAIC was an independent risk factor affecting the efficacy and prognosis of AML patients(P＜0.05,OR=1.205,95％CI:1.015-1.430).Conclusion Regular testing of D-D,FDP,TM,TAT,t-PAIC and PIC levels can help to assess the disease changes and efficacy prognosis of AML patients,and provide an important reference for clinical decision-making.关键词
急性白血病/凝血指标/纤溶指标/血栓调节蛋白/预后Key words
Acute leukemia/Coagulation index/Fibrinolytic index/Thrombomodulin/Prognosis分类
医药卫生引用本文复制引用
龚莉,罗锦英,陈国宁,童广福,王晓刚..凝血指标和纤溶指标在急性髓系白血病患者治疗中的水平变化及预测价值[J].中国现代医生,2025,63(27):19-22,92,5.基金项目
贺州市科学研究与技术开发计划项目(贺科技2023111) （贺科技2023111）
