中华中医药学刊2025，Vol.43Issue(10)：1-5,5.DOI:10.13193/j.issn.1673-7717.2025.10.001
3味山姜属中药挥发油对胃寒证大鼠体温及交感神经-肾上腺系统的影响
Effects of Essential Oil of Three Chinese Drugs of Alpinia on Body Temperature and Sympathetic-Adrenal System in Rats with Stomach Cold Syndrome
摘要
Abstract
Objective To observe the effects of volatile oil of Gaoliangjiang(Alpinia officinarum Hance),Dagaoliangjiang(Al-pinia galanga Willd)and Hongdoukou(Alpinia galanga Willd)on body temperature and sympathetic nerve-adrenal axis in rats with stomach cold syndrome and to explore the material basis of warm properties of three Chinese drugs of Alpinia.Methods A to-tal of 150 SPF grade SD male rats were selected,and 10 rats were randomly selected as the blank group.The other rats were sim-ulated the stomach cold syndrome by oral administration of Zimu decoction.After modeling,they were randomly divided into mod-el group,positive group,volatile oil of Gaoliangjiang(Alpinia officinarum Hance)high and low dose groups,volatile oil of Da-gaoliangjiang(Alpinia galanga Willd)high and low dose groups,volatile oil of Hongdoukou(Alpinia galanga Willd)high and low dose groups,Gaoliangjiang(Alpinia officinarum Hance)high and low dose groups,Dagaoliangjiang(Alpinia galanga Willd)high and low dose groups,Hongdoukou(Alpinia galanga Willd)high and low dose groups.With gingerol as the positive control,the a-nal temperature was determined by electronic thermometer,the body temperature of upper abdomen and mid-abdomen was deter-mined by infrared thermograph,and the contents of norepinephrine(NE),adrenocorticotropic hormone(ACTH),corticotropin re-leasing hormone(CRH),dopamine(DA),dopamine-β-hydroxylase(D-β-H),serotonin(5-HT),acetylcholinesterase(AchE)and 17 hydroxycorticosteroids(17-OHCS)were determined by ELISA.Results Compared with those of the blank group,the contents of NE,ACTH,CRH,DA,D-β-H,AchE and 17-OHCS in serum of rats with stomach cold syndrome were significantly decreased.The content of 5-HT was significantly increased.Compared with that of the model group,the content of ACTH in all other groups,except that in the volatile oil of Dagaoliangjiang(Alpinia officinarum Hance)low dose group and Hong-doukou(Alpinia officinarum Hance)volatile oil groups,was significantly increased.The 17-OHCS content was significantly in-creased in all groups except that in the low dose group of Gaoliangjiang(Alpinia officinarum Hance).The CRH content of rats was significantly increased except that in low dose groups of Gaoliangjiang(Alpinia officinarum Hance)and Hongdoukou(Alpinia galanga Willd).The D-β-H was significantly increased except that in low dose groups of Dagaoliangjiang(Alpinia galanga Willd)and Hongdoukou(Alpinia galanga Willd).The DA content of rats was significantly increased and the 5-HT was signifi-cantly decreased except those in the Hongdoukou(Alpinia galanga Willd)group.The AchE was significantly increased except that in the low dose group of Gaoliangjiang(Alpinia officinarum Hance).The NE in each administration group was significantly increased.Conclusion The essential oil of three Chinese drugs of Alpinia can regulate the function of sympathetic nerve and adre-nal axis in rats with stomach cold syndrome.关键词
山姜属中药/挥发油/胃寒证/体温/交感神经-肾上腺系统/药性Key words
Chinese drugs of Alpinia/volatile oil/stomach cold syndrome/body temperature sympathetic-adrenal system/drug properties分类
医药卫生引用本文复制引用
秦华珍,马小宾,江芳静,蒙宏杰,陈卓尔..3味山姜属中药挥发油对胃寒证大鼠体温及交感神经-肾上腺系统的影响[J].中华中医药学刊,2025,43(10):1-5,5.基金项目
国家自然科学基金项目(82074034) （82074034）
