中华中医药学刊2025，Vol.43Issue(10)：49-53,5.DOI:10.13193/j.issn.1673-7717.2025.10.010
消渴方加减治疗2型糖尿病肾病患者(气虚血瘀型)的临床研究
Clinical Study on Modified Xiaoke Decoction(消渴方加减)Treating Patients with Type 2 Diabetic Nephropathy (Qi Deficiency and Blood Stasis Type)
摘要
Abstract
Objective To analyze the clinical effect of Modified Xiaoke Decoction(消渴方加减)treating patients with type 2 diabetic nephropathy(Qi deficiency and blood stasis type).Methods A total of 220 patients with type 2 diabetic nephropathy of Qi deficiency and blood stasis type admitted to the Department of Endocrinology and Nephrology of Ziyang Hospital of Traditional Chinese Medicine from June 2020 to June 2024 were included as the research objects.They were divided into two groups by the random number table method.A hundred and ten patients in the control group were treated with conventional western medicine treatment,and the other 110 patients in the observation group were treated with Modified Xiaoke Decoction on this basis.The treatment effects,TCM symptom scores,blood glucose indexes,islet β cell functions,renal function indexes and changes in oxida-tive stress indexes of the two groups were compared.Results The total effective rate of the observation group was 97.28％(107/110),which was much higher than that of the control group(82.73％,91/110),and the difference between the groups was signif-icant(P＜0.05).After treatment,the levels of fasting blood glucose(FPG),2-hour postprandial blood glucose(2 h PBG).gly-cated hemoglobin(HbA1 c)and homeostasis model assessment of insulin resistance(HOM A-IR)in the observation group were lower than those in the control group,and homeostasis model assessment-β(HOMA-β)was higher than that in the control group(P＜0.05).After treatment,the levels of 24-hour urinary protein and urinary β2-microglobulin(β2 MG)in the observa-tion group were lower than those in the control group(P＜0.05).After treatment,the levels of superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px)in the observation group were higher than those in the control group,and the level of malondi-aldehyde(MDA)was lower than that in the control group(P＜0.05).Conclusion The application of Modified Xiaoke Decoction in patients with type 2 diabetic nephropathy of Qi deficiency and blood stasis type can effectively reduce the blood glucose level,improve insulin resistance and islet β cell function,inhibit the oxidative stress reaction,protect renal function,reduce damage,and has a positive effect on the improvement of the prognosis of patients.关键词
2型糖尿病肾病/消渴方/气虚血瘀型/肾功能/血糖指标/氧化应激反应/中西医结合治疗Key words
type 2 diabetic nephropathy/Xiaoke Decoction(消渴方)/Qi deficiency and blood stasis type/renal function/blood glucose index/oxidative stress reaction/integrated treatment of traditional Chinese and western medicine分类
医药卫生引用本文复制引用
汪道贵,刘火锋,周华..消渴方加减治疗2型糖尿病肾病患者(气虚血瘀型)的临床研究[J].中华中医药学刊,2025,43(10):49-53,5.基金项目
国家重点研发计划项目(2018YFC1707606) （2018YFC1707606）
