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Pyrimethamine Inhibits Human Ovarian Cancer by Triggering Lethal Mitophagy via Activating the p38/JNK/ERK Pathway

Lingjuan Linghu Hongying Zhou Gang Zheng Tao Yi

Oncology Research2025，Vol.33Issue(9)：P.2421-2434,14.

Oncology Research2025，Vol.33Issue(9)：P.2421-2434,14.DOI:10.32604/or.2025.063724

Pyrimethamine Inhibits Human Ovarian Cancer by Triggering Lethal Mitophagy via Activating the p38/JNK/ERK Pathway

Lingjuan Linghu ¹Hongying Zhou ²Gang Zheng ¹Tao Yi¹

作者信息

1. Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province,Key Laboratory of Birth Defects and Related Diseases of Women and Children,Ministry of Education,West China Second Hospital,Sichuan University,Chengdu,610041,China
2. Department of Human Anatomy,West China School of Preclinical and Forensic Medicine,Sichuan University,Chengdu,610041,China
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摘要

关键词

Pyrimethamine/drug repurposing/ovarian cancer/mitophagy/P38/JNK/ERK pathway

分类

医药卫生

引用本文复制引用

Lingjuan Linghu,Hongying Zhou,Gang Zheng,Tao Yi..Pyrimethamine Inhibits Human Ovarian Cancer by Triggering Lethal Mitophagy via Activating the p38/JNK/ERK Pathway[J].Oncology Research,2025,33(9):P.2421-2434,14.

基金项目

supported by the Natural Science Foundation of Sichuan Province,China,grant number:2021YJ0011. （）

Oncology Research

ISSN：0965-0407

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