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Lycium barbarum glycopeptide ameliorates aberrant neuronal activity via ER stress modulation in ventral forebrain organoids derived from depressive patients

Meng-Dan Tao Can Wang Xin-Hao Wu Qi Chen Wei-Wei Gao Min Xu Yuan Hong Xiao Han Wan-Ying Zhu Qian Zhu Yan Liu Xing Guo

Zoological Research2025，Vol.46Issue(4)：P.841-850,10.

Zoological Research2025，Vol.46Issue(4)：P.841-850,10.DOI:10.24272/j.issn.2095-8137.2025.016

Lycium barbarum glycopeptide ameliorates aberrant neuronal activity via ER stress modulation in ventral forebrain organoids derived from depressive patients

Meng-Dan Tao ¹Can Wang ¹Xin-Hao Wu ²Qi Chen ³Wei-Wei Gao ³Min Xu ³Yuan Hong ³Xiao Han ¹Wan-Ying Zhu ³Qian Zhu ³Yan Liu ¹Xing Guo⁴

作者信息

1. Institute for Stem Cell and Neural Regeneration,School of Pharmacy,Nanjing Medical University,Nanjing,Jiangsu 211166,China State Key Laboratory of Reproductive Medicine,Nanjing Medical University,Nanjing,Jiangsu 211166,China
2. Department of Neurobiology,School of Basic Medical Sciences,Nanjing Medical University,Nanjing,Jiangsu 211166,China
3. Institute for Stem Cell and Neural Regeneration,School of Pharmacy,Nanjing Medical University,Nanjing,Jiangsu 211166,China
4. State Key Laboratory of Reproductive Medicine,Nanjing Medical University,Nanjing,Jiangsu 211166,China Department of Neurobiology,School of Basic Medical Sciences,Nanjing Medical University,Nanjing,Jiangsu 211166,China Second Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210011,China
折叠

摘要

关键词

Disease modeling/GABAergic interneuron/iPSCs/Major depressive disorder/Organoids

分类

医药卫生

引用本文复制引用

Meng-Dan Tao,Can Wang,Xin-Hao Wu,Qi Chen,Wei-Wei Gao,Min Xu,Yuan Hong,Xiao Han,Wan-Ying Zhu,Qian Zhu,Yan Liu,Xing Guo..Lycium barbarum glycopeptide ameliorates aberrant neuronal activity via ER stress modulation in ventral forebrain organoids derived from depressive patients[J].Zoological Research,2025,46(4):P.841-850,10.

基金项目

supported by the National Key Research and Development Program of China(2021YFA1101800,2022YFA1104800,2023YFF1203600) （2021YFA1101800,2022YFA1104800,2023YFF1203600）

National Natural Science Foundation of China(82325015,82171528,U23A20429,82371260,21904069,22274079,82401794) （82325015,82171528,U23A20429,82371260,21904069,22274079,82401794）

Jiangsu Provincial Natural Science Fund for Excellent Young Scholars(BK20240131) （BK20240131）

Natural Science Foundation of Jiangsu Province(BK20200677) （BK20200677）

Joint Project of the Yangtze River Delta Science and Technology Innovation Community(2024CSJZN0600)。（2024CSJZN0600）

Zoological Research

ISSN：2095-8137

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