辐射研究与辐射工艺学报2025，Vol.43Issue(5)：43-53,11.DOI:10.11889/j.1000-3436.2025-0021
基于数字微流控芯片的NOTA-奥曲肽的Al18F标记工艺
Al18F labeling process for NOTA-octreotide based on digital microfluidic chips
摘要
Abstract
This study proposes a new synthesis process for 18F-AlF-NOTA-octreotide based on digital microfluidic chip technology.Through electrowetting on dielectric(EWOD)technology,parallel multi-channel synthesis was achieved on the microfluidic chip,effectively addressing issues such as technical complexity,high costs,low production efficiency,and concerns related to safety and environmental protection in conventional synthesis methods.Under the optimized reaction conditions(reaction temperature of 120 ℃,reaction time of 5 min,precursor concentration of 0.2 mg/mL),the highest radiochemical yield reached 24.85%,and the radiochemical purity of the product was greater than 99.0%.This method significantly reduced initial equipment investment(by 50%-60%)and the cost per synthesis(by 71%-72%),while also shortening the synthesis time to 15-20 min and reducing radioactive waste generation.This process offers an efficient,low-cost,and environmentally friendly new strategy for the synthesis of clinical PET tracers.关键词
数字微流控芯片/放射性药物/氟-18/NOTA-奥曲肽Key words
Digital microfluidic chip/Radiopharmaceutical/Fluorine-18/NOTA-octreotide分类
能源科技引用本文复制引用
王飞鸿,和庆钢,陈俊威,姚琼,毛迪龙,金晨涛,龚懿德,潘建章,张宏,王菁..基于数字微流控芯片的NOTA-奥曲肽的Al18F标记工艺[J].辐射研究与辐射工艺学报,2025,43(5):43-53,11.基金项目
国家自然科学基金(32027802,22178307)、国家重点研发计划项目(2021YFA1101700)和浙江省科学技术厅(2024C03100,2022C03071) Supported by National Natural Science Foundation of China(32027802,22178307),the National Key R&D Program of China(2021YFA1101700),and the Science Technology Department of Zhejiang Province(2024C03100,2022C03071) （32027802,22178307）
