广东药科大学学报2025，Vol.41Issue(5)：158-166,9.DOI:10.16809/j.cnki.2096-3653.2025043003
mRNA技术及其医药应用研究进展
Research progress on mRNA technology and its medical applications
摘要
Abstract
Messenger ribonucleic acid(mRNA)technology,characterized by its flexible design,efficient production,controllable cost,short research and development cycle,is widely applied in the prevention and treatment of infectious diseases,tumor immunotherapy and genetic disease treatment,and has become a research hotspot in the field of biomedicine.In recent years,significant progress has been made in mRNA technology in areas such as sequence optimization,development of novel modified nucleotides,modification of key enzymes,quality control,delivery vectors and application.This review summarizes the recent research progress of mRNA technology and provides valuable references for the future research and application of mRNA technology.关键词
mRNA技术/T7 RNA聚合酶改造/mRNA递送/mRNA应用Key words
mRNA technology/T7 RNA polymerase engineering/mRNA delivery/mRNA application分类
医药卫生引用本文复制引用
林继琼,宋祥,白健,王淑美,王升启..mRNA技术及其医药应用研究进展[J].广东药科大学学报,2025,41(5):158-166,9.基金项目
国家重点基础研究发展计划项目(2018YFA0902300) （2018YFA0902300）
国家自然科学基金(82402178) （82402178）
