广州化学2025，Vol.50Issue(5)：1-7,7.DOI:10.16560/j.cnki.gzhx.20250515
金硅纳米棒等离子激元用于药物释放的动态监测
Gold-silicon Nanorod Plasmonics for Dynamic Drug Release Monitoring
摘要
Abstract
It was successfully constructed that gold-silicon nanorod plasmonic excitations[DOX-AuNRs@SiO2/Zn(OH)2]encapsulating the chemotherapeutic drug adriamycin(DOX).The nano-delivery system was able to remain stable under neutral physiological conditions,and when entering the weakly acidic environment of tumor cells,the Zn(OH)2 layer was rapidly dissolved,triggering rapid drug release.Real-time monitoring of individual nanocarriers by dark-field microscopy revealed that there was a linear relationship between the amount of DOX release and the degree of blue-shift of plasma exciton resonance scattered light during drug release.In addition,this plasma exciton nanocarrier system enables real-time visualization and tracking of the drug release kinetics in individual tumor cells,providing a new strategy for quantitative analysis of drug delivery systems and evaluation of drug efficacy.关键词
金硅纳米棒/等离子体共振/暗场显微镜/动态监测Key words
gold-silicon nanorod/plasmon resonance/dark-field microscopy/dynamic monitoring分类
化学化工引用本文复制引用
邹其融,沈晶晶,孙乐,蔡鑫龙,蔡苗苗,周洋,张磊..金硅纳米棒等离子激元用于药物释放的动态监测[J].广州化学,2025,50(5):1-7,7.基金项目
国家自然科学基金(22374081,22204081) （22374081,22204081）
江苏省"青蓝工程"学术带头人项目以及南京邮电大学基金(GZR2023010049,GZR2024010006,NY222022) （GZR2023010049,GZR2024010006,NY222022）
江苏省研究生科研与实践创新计划项目(ProvinceKYCX25_1186) （ProvinceKYCX25_1186）
