广州化学2025，Vol.50Issue(5)：14-20,7.DOI:10.16560/j.cnki.gzhx.20252704
盐酸他喷他多的不对称合成进展
Progress of Asymmetric Synthesis of Tapentadol Hydrochloride
任楚楚 1王国平 2苏霜霜 2吴雪松 2王宏博2
作者信息
- 1. 上海工程技术大学 化学化工学院,上海 201620||中国医药工业研究总院 上海医药工业研究院有限公司,上海 201203
- 2. 中国医药工业研究总院 上海医药工业研究院有限公司,上海 201203
- 折叠
摘要
Abstract
This review summarizes recent advances in the asymmetric synthesis of tapentadol,with a detailed focus on three key strategies:substrate-controlled induction,chiral auxiliary-assisted induction,and asymmetric catalysis.The design and optimization of synthetic routes based on these approaches are thoroughly discussed.By evaluating recently reported routes(within the last decade)against critical criteria such as stereoselectivity,reaction yield,and industrial feasibility,this work provides a comparative and critical analysis of various synthetic processes.The aim is to offer valuable insights and practical references for the efficient and environmentally sustainable industrial production of tapentadol.关键词
盐酸他喷他多/手性拆分/不对称催化/合成Key words
tapentadol hydrochloride/chiral resolution/asymmetric catalysis/synthesis分类
医药卫生引用本文复制引用
任楚楚,王国平,苏霜霜,吴雪松,王宏博..盐酸他喷他多的不对称合成进展[J].广州化学,2025,50(5):14-20,7.
