广州化学2025，Vol.50Issue(5)：61-66,6.DOI:10.16560/j.cnki.gzhx.20250507
5,10,15,20-四对氨基苯基卟啉锌及SiO2-MSN复合纳米材料的合成及抗菌性能
Synthesis and Antibacterial Evaluation of Zinc[5,10,15,20-Tetrakis(4-aminophenyl)porphyrin]and SiO2-MSN Composite Nanomaterials
陈铭睿 1靳焘2
作者信息
- 1. 中国科学院广州化学研究所,广东 广州 510650||中国科学院大学,北京 100049
- 2. 中国科学院广州化学研究所,广东 广州 510650||中国科学院大学,北京 100049||中科检测技术服务(广州)股份有限公司,广东 广州 510650||中国科学院新型特种精细化学品工程实验室,广东 广州 510650||国科广化韶关新材料研究院,广东 南雄 512400||国科广化(南雄)新材料研究院有限公司,广东 南雄 512400
- 折叠
摘要
Abstract
To address the issue of antibiotic resistance posed by superbugs.This paper synthesized a novel amino porphyrin zinc-SiO2-MSN composite photosensitizer material through the 1/4 method using pyrrole,p-nitrobenzaldehyde,and other experimental raw materials,providing a new fundamental material for photodynamic sterilization.Moreover,the stability and water solubility of the material were improved by modifying the organic compounds and designing the carrier.Subsequently,techniques such as H-NMR,XPS,ESR,EPR,FT-IR and bacterial culture were employed to confirm the material's special structure of 5,10,15,20-tetrakis(4-aminophenyl)porphyrin,and to verify that SiO2-MSN is a porous microsphere with a large number of small pores and a nanoscale size of only 100 nm.Furthermore,these methods were used to validate the loading of the organic compound on the surface of the nano-microspheres and the mechanism of action,as well as the actual antibacterial effects of the composite material.It has been confirmed that the material has a very strong potential for practical application and is a strong contender for photosensitizer materials in future photodynamic therapy.关键词
卟啉/纳米粒子/光催化/灭菌/水溶性Key words
porphyrin/nanoparticle/photocatalysis/sterilization/water solubility分类
医药卫生引用本文复制引用
陈铭睿,靳焘..5,10,15,20-四对氨基苯基卟啉锌及SiO2-MSN复合纳米材料的合成及抗菌性能[J].广州化学,2025,50(5):61-66,6.
