广州医药2025，Vol.56Issue(9)：1189-1200,12.DOI:10.20223/j.cnki.1000-8535.2025.09.005
肿瘤微环境响应型多柔比星前药的研究进展
Research progress of doxorubicin prodrug based on tumor microenvironment response
摘要
Abstract
Compared with normal tissue cell microenvironment,there is some differences in tumor microenvironment,such as partial acidity,imbalance of redox state,high concentration of reactive oxygen species and cathepsin.According to the above characteristics of tumor microenvironment,a series of small molecule or polymer prodrug nanoparticles connected by various special microenvironment responsive structures can be designed.Doxorubicin,as one of the most common broad-spectrum antitumor drugs,plays an important role in the treatment of tumors.This review discusses the doxorubicin prodrug designed for different tumor microenvironments under the physiological state of tumor microenvironment specificity and their release characteristics,and summarizes the research progress of tumor microenvironment-responsive doxorubicin prodrug.关键词
肿瘤微环境/多柔比星前药/肿瘤治疗/谷胱甘肽/活性氧Key words
tumor microenvironment/doxorubicin prodrug/tumor therapy/glutathione/reactive oxygen species引用本文复制引用
王悦,马文静,侯金松,吴豪..肿瘤微环境响应型多柔比星前药的研究进展[J].广州医药,2025,56(9):1189-1200,12.基金项目
安徽省教育厅高校科学研究一般项目(KJ2021B16) （KJ2021B16）
