内科理论与实践2025，Vol.20Issue(4)：296-300,5.DOI:10.16138/j.1673-6087.2025.04.06
老年脑卒中患者预后不良危险因素筛选及其相互作用探索
Screening of risk or protective factors for prognosis and their interaction in elderly patients with stroke
徐婷 1戎捷骊 1顾仁丽 1徐阳 2刘小江1
作者信息
- 1. 海安市人民医院 神经外科,江苏 海安 226600
- 2. 海安市人民医院 创伤外科,江苏 海安 226600
- 折叠
摘要
Abstract
Objective To explore the risk or protective factors and their interactions for recurrence after acute ischemic stroke(AIS).Methods A total of 143 AIS patients admitted in our hospital from March 2020 to March 2023 were selected and followed up,and general clinical data were collected.Twelve patients were lost to follow-up.The end point of follow-up was stroke recurrence.The risk factors of stroke recurrence were screened by COX analysis,and the interaction between risk factors was analyzed.Results Univariate COX analysis showed that age,modified Rankin scale(mRS)score,the National Institutes of Health stroke scale(NIHSS)score,activated partial thrombin time and diabetes history were risk factors for poor prognosis in elderly patients with AIS[hazard ratio(HR)>1,P<0.05].Montreal cognitive assessment scale(MoCA)score and fibrinogen are protective factors for good prognosis in elderly patients with AIS(HR<1,P>0.05).Multivariate COX analysis showed that mRS score and NIHSS score were independent risk factors for poor prognosis in elderly patients with AIS(HR>1,P>0.05).MoCA score and fibrinogen are protective factors for good prognosis in elderly patients with AIS(HR<1,P>0.05).Patients with high mRS score and high NIHSS score had worse prognosis(P<0.001).Patients with high MoCA score and high fibrinogen level had better prognosis(P<0.001).mRS score,NIHSS score,MoCA score and fibrinogen level had no significant interaction.Conclusions mRS score and NIHSS score are independent risk factors for poor prognosis in elderly patients with AIS.MoCA score and independent protective factor of good prognosis in elderly patients with AIS of fibrinogen.There was no significant interaction between these risk factors and protective factors.关键词
老年/急性缺血性脑卒中/复发/危险因素Key words
Elderly/Acute ischemic stroke/Recurrence/Risk factor分类
医药卫生引用本文复制引用
徐婷,戎捷骊,顾仁丽,徐阳,刘小江..老年脑卒中患者预后不良危险因素筛选及其相互作用探索[J].内科理论与实践,2025,20(4):296-300,5.
