内科理论与实践2025，Vol.20Issue(4)：322-327,6.DOI:10.16138/j.1673-6087.2025.04.12
抗肿瘤药物所致血栓性微血管病样肾损伤2例
Renal thrombotic microangiopathy associated with chemotherapy:two case reports
王祎宁 1陈楠楠 2程琳 3刘振华 4郑晓燕 5徐静 6潘晓霞 6陈永熙 6陈晓农6
作者信息
- 1. 上海交通大学医学院附属瑞金医院 肾脏科,上海 200025||上海交通大学医学院附属瑞金医院舟山分院 肾脏科,浙江 舟山 316000
- 2. 上海交通大学医学院附属瑞金医院舟山分院 肾脏科,浙江 舟山 316000
- 3. 上海交通大学医学院附属瑞金医院舟山分院 超声科,浙江 舟山 316000
- 4. 上海交通大学医学院附属瑞金医院 超声科,上海 200025||上海交通大学医学院附属瑞金医院舟山分院 超声科,浙江 舟山 316000
- 5. 上海交通大学医学院附属瑞金医院舟山分院 呼吸科,浙江 舟山 316000
- 6. 上海交通大学医学院附属瑞金医院 肾脏科,上海 200025
- 折叠
摘要
Abstract
Patient 1 was a 68-year-old male who had been diagnosed with a malignant lung tumor for three years.This case developed proteinuria during bevacizumab treatment and had normal renal function.Patient 2 was a 70-year-old male diagnosed with gastric adenocarcinoma for two years,this case developed proteinuria after three months chemotherapy with oxaliplatin,leucovorin,and fluorouracil,but his renal function was normal.Renal biopsy of the two patients showed thrombotic microangiopathy.After treatment with sacubitril/valsartan sodium combined with dapagliflozin,proteinuria in two patients decreased,and their renal function was still stable.关键词
血栓性微血管病/抗肿瘤药物/肾损伤Key words
Thrombotic microangiopathy/Antineoplastic agents/Renal involvement分类
医药卫生引用本文复制引用
王祎宁,陈楠楠,程琳,刘振华,郑晓燕,徐静,潘晓霞,陈永熙,陈晓农..抗肿瘤药物所致血栓性微血管病样肾损伤2例[J].内科理论与实践,2025,20(4):322-327,6.
