肿瘤预防与治疗2025，Vol.38Issue(10)：882-887,6.DOI:10.3969/j.issn.1674-0904.2025.10.005
瑞马唑仑与丙泊酚用于宫颈癌患者多次组织间插植放疗镇静的自身对照研究
Effects of Remimazolam versus Propofol for Sedation during Multiple-Fraction Interstitial Brachytherapy in Cervical Cancer Patients:A Within-Subject Study
摘要
Abstract
Objective:To compare the safety and efficacy of remimazolam and propofol for sedation in the same patients undergoing multiple fractions of interstitial brachytherapy for cervical cancer.Methods:Thirty-six cervical cancer patients who required at least two sessions of interstitial brachytherapy were enrolled.Using a random number table,patients were allocated to one of two sedation protocols for their initial two treatments:propofol 1.5 mg/kg or remimazolam 0.3 mg/kg,each combined with sufentanil 0.1 μg/kg.The primary out-come was the incidence of respiratory depression.Secondary outcomes included the incidence of adverse reactions such as hy-potension and injection pain,the success rate of first sedation,the onset time of sedative drugs,and the maintenance time of a single sedative dose.Results:Remimazolam significantly reduced the incidence of respiratory depression(5.6％vs 27.8％,P=0.008),hypotension(22.2％vs 52.8％,P=0.001),and injection pain(2.8％vs 33.3％,P=0.001)compared to propofol.There was no significant difference in the success rate of initial sedation between remimazolam and propofol(94.4％vs 97.2％,P＞0.05).Patients receiving remimazolam demonstrated a significantly longer onset time[(31.0±3.9)s vs(28.6±3.6)s,P=0.001]and a shorter maintenance time per single dose[(180.3±19.7)s vs(204.1±14.6)s,P＜0.001]compared to those who received propofol.Conclusion:During repeated sedation for inter-stitial brachytherapy in the same cervical cancer patients,remimazolam offered a more favorable safety profile with enhanced respiratory and circulatory stability compared to propofol.Therefore,remimazolam represents a safer sedative option for inter-stitial brachytherapy in cervical cancer patients.关键词
瑞马唑仑/丙泊酚/组织间插植放疗/镇静Key words
Remimazolam/Propofol/Interstitial brachytherapy/Sedation分类
医药卫生引用本文复制引用
舒进军,孙佳昕,王怀明,杨涵丹,王艳青,谭晓红,曾德玲..瑞马唑仑与丙泊酚用于宫颈癌患者多次组织间插植放疗镇静的自身对照研究[J].肿瘤预防与治疗,2025,38(10):882-887,6.基金项目
This study was supported by grants from Sichuan Medical Association(No.2024HR76).四川省医学会麻醉专项科研项目(编号:2024HR76) （No.2024HR76）
