肿瘤预防与治疗2025，Vol.38Issue(10)：888-895,8.DOI:10.3969/j.issn.1674-0904.2025.10.006
肺癌初诊患者首次中心静脉置管所致导管相关深静脉血栓的发生率及危险因素分析
Incidence and Risk Factors for Central Venous Catheter-Associated Deep Venous Thrombosis in Newly Diagnosed Lung Cancer Patients
摘要
Abstract
Objective:To investigate the incidence and risk factors of catheter-associated deep vein thrombosis(CAD-VT)following initial central venous catheterization in newly diagnosed lung cancer patients,to provide evidence for its early identification.Methods:We enrolled 480 newly diagnosed lung cancer patients who received central venous catheter(CVC)catheterization at the Lung Cancer Center of West China Hospital from November 2022 to October 2023.These patients were categorized into CADVT and non-CADVT groups based on the occurrence of CADVT post-catheterization.Clinical data and hematological parameters were collected from the two groups.Multivariable logistic regression was used to identify risk factors for catheter-associated deep vein thrombosis(CADVT)following CVC catheterization in lung cancer patients.Results:The incidence of CADVT among the 480 patients was 9.8％(47/480).Univariate analysis and multivariable logistic regression analysis identified several independent risk factors for CADVT after first-time CVC catheterization in patients with newly diag-nosed lung cancer(P＜0.05).These included diabetes mellitus(OR=5.085,95％CI:1.284～20.133),TNM stageⅣ(OR=5.268,95％CI:1.287～21.555),Number of punctures ≥ 2(OR=13.527,95％CI:2.781～65.800),catheterization duration＞5 days(OR=29.540,95％CI:3.597～242.625),History of previous cerebral infarction(OR=48.080,95％CI:2.700～856.239)and diuretic use(OR=6.003,95％CI:1.073～33.577).Furthermore,ele-vated levels of fibrinogen(OR=1.909,95％CI:1.156～3.153),antithrombin(OR=1.087,95％CI:1.035～1.142),D-dimer(OR=1.452,95％CI:1.240～1.699),and indirect bilirubin(OR=1.446,95％CI:1.146～1.825)were associated with increased risk,while a decreased level of Albumin-to-Globulin ratio(OR=0.744,95％CI:0.657～0.843)and total protein(OR=0.874,95％CI:0.826～0.925)were protective factor.Conclusion:In our center,the incidence of CADVT after first-time CVC catheterization in newly diagnosed lung cancer patients was 9.8％,with key independent risk factors including abnormal psychological state,diabetes,advanced TNM stage,elevated D-dimer,and decreased total protein.The early identification of these factors is essential for the prevention of CADVT.关键词
肺癌/血栓/危险因素/华西心晴指数/中心静脉导管Key words
Lung cancer/Thrombosis/Risk factors/Huaxi emotional-distress index(HEI)/Central venous catheter分类
医药卫生引用本文复制引用
周丽,王力,徐丹,王梦,张衍..肺癌初诊患者首次中心静脉置管所致导管相关深静脉血栓的发生率及危险因素分析[J].肿瘤预防与治疗,2025,38(10):888-895,8.基金项目
This study was supported by grants from Health Com-mission of Sichuan Province(No.21PJ006)and Chengdu Science and Technology Bureau(No.2022-YF05-01420-SN).四川省卫生健康委员会医学科技项目(编号:21PJ006) （No.21PJ006）
成都市科技局项目(编号:2022-YF05-01420-SN) （编号:2022-YF05-01420-SN）
