肿瘤预防与治疗2025，Vol.38Issue(10)：896-904,9.DOI:10.3969/j.issn.1674-0904.2025.10.007
自动乳腺全容积成像技术联合多模态超声特征观察对进展期乳腺癌新辅助化疗疗效评估的价值
Value of Automated Breast Volume Scanner Combined with Multimodal Ultrasound Features in Evaluating the Efficacy of Neoadjuvant Chemo-therapy for Advanced Breast Cancer
摘要
Abstract
Objective:To explore the value of automated breast volume scanner(ABVS)combined with multimodal ul-trasound features in evaluating the efficacy of neoadjuvant chemotherapy(NAC)for advanced breast cancer.Methods:A total of 126 patients with advanced breast cancer scheduled for NAC and subsequent surgery were enrolled from CangZhou Hospital of Integrated Traditional Chinese and Western Medicine in Hebei Province between July 2022 and May 2024.All patients were examined using both the ABVS and multimodal ultrasound.Based on the modified Miller and Payne pathologic response grading criteria,the patients were categorized into groups.The ABVS tumor volume parameters,multimodal ultra-sound features,and their changes were then compared among these groups.A logistic regression analysis was performed to i-dentify independent predictors of pathological complete response(pCR),including the reduction rates of the maximum tumor volume(Vmax)at 2 cycles and overall,the rate of change in the maximum diameter,the resistance index(RI),and the vas-cularization index(VI).Results:We enrolled 126 patients with advanced breast cancer based on the criteria.During treat-ment,two patients died(one cancer-related and one non-disease-related),two transferred to other hospitals,and two with-drew,leaving 120 patients who completed the treatment and follow-up examinations.Based on the postoperative pathological assessment,patients were stratified into three groups:a pCR group(n=25),a partial response group(n=49),and a non-response group(n=46).No significant differences were found in baseline characteristics-including age,menopause status,pathological classification,pathological stage,tumor diameter,human epidermal growth factor receptor 2 expression,estrogen receptor expression,progesterone receptor expression,Ki-67 index,molecular classification,disease-free survival,and overall survival-among the three groups(all P＞0.05).The partial response group had a lower proportion of patients with lymph node metastasis compared to the non-response group(P＜0.05).Patients in the pCR and partial response groups had significantly smaller maximum tumor volumes(Vmax)both after 2 cycles of treatment and at the end of treatment than those in the non-response group.Conversely,the 2-cycle change in Vmax(△Vmax),the total △Vmax,the 2-cycle Vmax reduction rate,and the total Vmax reduction rate were all significantly greater in these two response groups compared to the non-response group(all P＜0.05).At the end of treatment,the pCR and partial response groups showed significantly lower values for tumor maximum diameter,spiculation sign detection rate,RI,VI,and elasticity score than the non-response group.Conversely,the rates of change in the maximum diameter,RI,and VI were significantly greater in the response groups(all P＜0.05).Logistic regression analysis identified the following as independent predictors of pCR following NAC for advanced breast cancer:the 2-cycle Vmax reduction rate,the total Vmax reduction rate,the rates of change in the maxi-mum diameter,RI,and VI(all P＜0.05).Conclusion:The combination of ABVS and multimodal ultrasound features is valuable for assessing the response to NAC in patients with advanced breast cancer.关键词
自动乳腺全容积成像技术/乳腺超声检查/乳腺肿瘤/新辅助治疗/血流动力学Key words
Automated breast volume scanner/Breast ultrasonography/Breast neoplasms/Neoadjuvant therapy/Hemo-dynamics分类
医药卫生引用本文复制引用
黄梅,张超,朱丽,陈秀霞,王书新,毛剑..自动乳腺全容积成像技术联合多模态超声特征观察对进展期乳腺癌新辅助化疗疗效评估的价值[J].肿瘤预防与治疗,2025,38(10):896-904,9.基金项目
河北省卫生健康委科研基金项目(编号:20220693)This study was supported grants from Health Commission of Hebei Province(No.20220693). （编号:20220693）
