肿瘤预防与治疗2025，Vol.38Issue(10)：918-926,9.DOI:10.3969/j.issn.1674-0904.2025.10.010
检测方式及变体类型对晚期ALK融合非小细胞肺癌预后影响的研究进展
Research Progress on the Influence of Detection Methods and Variant Types on the Prognosis of Advanced ALK Fusion-Positive Non-Small Cell Lung Cancer
摘要
Abstract
Anaplastic lymphoma kinase(ALK)fusion gene is one of the important driver gene mutations in non-small cell lung cancer(NSCLC).There are various and continuously evolving detection methods for it.Moreover,different ALK fusion variant types exhibit differences in the bi-ological behavior and prognosis among NSCLC patients.This article reviews the common methods for detecting ALK fu-sions,including the roles,characteristics,and limitations of different detection methods-such as fluorescence in situ hy-bridization,immunohistochemistry,polymerase chain reaction,and next-generation sequencing-in prognostic evaluation of NSCLC.The article also discusses how different ALK fusion variants influence patient treatment responses and prognosis in both clinical studies and real-world practice.The goal of this review is to inform the precise diagnosis,individualized treat-ment,and prognosis assessment of ALK-positive NSCLC patients,and to identify promising avenues for future research.关键词
ALK融合基因/非小细胞肺癌/检测方式/变体类型Key words
ALK fusion gene/Non-small cell lung cancer/Detection method/Variant type分类
医药卫生引用本文复制引用
骆珊,王绎,梁泓宇,杨一,谢华..检测方式及变体类型对晚期ALK融合非小细胞肺癌预后影响的研究进展[J].肿瘤预防与治疗,2025,38(10):918-926,9.基金项目
This study was supported by grants from Wu Jieping Medical Foundation(No.320.6750.2021-22-19)and Sichuan Anti-cancer Association(No.040).吴阶平医学基金会临床科研专项资助基金项目(编号:320.6750.2021-22-19) （No.320.6750.2021-22-19）
四川省抗癌协会XH2023自由探索项目(编号:040) （编号:040）
