摘要
Abstract
Objective:To To explore the application value of cervical liquid-based cytology(TCT)combined with high-risk human papillomavirus(HPV)detection in cervical precancerous lesions and cervical cancer screening.Methods:From July 2020 to July 2024,60 patients who needed cervical precancerous lesions and cervical cancer screening were analyzed retrospectively.All patients received TCT examination and high-risk HPV detection.Taking the results of colposcopy pathological biopsy as the gold standard,the detection rate of cervical precancerous lesions and cervical cancer by TCT and high-risk HPV detection,the consistency of joint detection and colposcopy pathological biopsy re-sults,and the diagnostic efficiency of cervical precancerous lesions and cervical cancer were analyzed.Results:Among the 60 patients,the results of colposcopy pathological biopsy showed that there were 48 cases of cervical precancerous lesions and cervical cancer,the detection rate was 48/60(80.00%).The results of TCT examination and colposcopy biopsy were generally consistent(kappa=0.587).The consistency between high-risk HPV and colposcopy patho-logical biopsy was acceptable(kappa=0.673).The results of TCT combined with high-risk HPV examination were consistent with those of colposcopy pathological biopsy(kappa=0.826).The specificity(91.67%)、sensitivity(93.75%)、positive predictive value(97.82%)、negative predictive value(78.57%)and diagnostic accuracy(93.33%)of TCT combined with high-risk HPV detection in the diagnosis of cervical precancerous lesions and cer-vical cancer were higher than those of TCT and high-risk HPV detection alone,P<0.05.Conclusion:TCT examina-tion and high-risk HPV detection have high diagnostic value for cervical precancerous lesions and cervical cancer,and their combined diagnosis has higher sensitivity,specificity and accuracy.关键词
宫颈液基细胞学/高危型人乳头瘤病毒/宫颈癌前病变/宫颈癌/筛查Key words
Liquid-based cytology of cervix/High-risk human papillomavirus/Cervical precancerous lesions/Cervi-cal cancer/Screen分类
医药卫生
