实用医学杂志2025，Vol.41Issue(20)：3191-3197,7.DOI:10.3969/j.issn.1006-5725.2025.20.007
基于肠道菌群理论探讨益生菌联合运动康复在帕金森病患者中的疗效
The efficacy of probiotics combined with exercise rehabilitation in Parkinson's disease patients was investigated based on the theory of intestinal flora
摘要
Abstract
Objective To investigate the effects of gut microbiota regulation combined with exercise rehabilitation on non-motor symptoms and neurological function in Parkinson's disease patients.Methods A total of 154 Parkinson's disease patients admitted to our hospital from January 2022 to January 2024 were selected as the subjects of the study.Using a random number table,these 154 patients were evenly divided into a control group and a treatment group,with 77 patients in each group.Both groups received standard treatments,but the control group also underwent exercise rehabilitation therapy,while the treatment group received probiotic supplementation and exercise rehabilitation therapy.The effectiveness of the two groups was then compared.Results Following the 12 weeks,24 weeks therapeutic regimen,The treatment group showed significantly better outcomes(P<0.05).Clinically meaningful reductions were observed in Hoehn-Yahr staging,alongside decreased scores on standardized instruments assessing psychiatric symptoms HAMA,HAMD,SCOPA-AUT,UPDRS Ⅰ-IV and PDSS(P<0.05).Concurrently,the study group exhibited enhanced MMSE(P<0.05).Fecal microbiome analyses revealed a favorable ecological shift characterized by increased colonization of beneficial genera Bifidobacterium and Lactobacillus,with concomitant suppression of pathobionts Enterococcus and Enterobacteriaceae.Gait analysis revealed increased step length,speed,and frequency in the treatment group(P<0.05).Conclusion Patients with Parkinson's disease who received probiotics combined with exercise rehabilitation treatment could effectively improve non-motor symptoms and neurological function,while promoting the balance of intestinal flora,and reduce clinical symptoms.关键词
肠道菌群/运动康复/帕金森病/非运动症状/神经功能Key words
intestinal flora/exercise rehabilitation/Parkinson's disease/non-motor symptoms/neurological function分类
医药卫生引用本文复制引用
杨杰,邓淑坤,袁鹏,师亚晨,马雪梅,苏旻..基于肠道菌群理论探讨益生菌联合运动康复在帕金森病患者中的疗效[J].实用医学杂志,2025,41(20):3191-3197,7.基金项目
国家自然科学基金项目(编号:82301715) （编号:82301715）
无锡市人民医院"雁阵人才"青年拔尖人才项目(编号:2025-YZ-QNBJ-DSK-2025) （编号:2025-YZ-QNBJ-DSK-2025）
无锡市卫生健康委适宜技术推广项目(编号:T202308) （编号:T202308）
