武警医学2025，Vol.36Issue(10)：866-870,5.
食管胃底静脉曲张患者行无痛胃镜治疗瑞马唑仑与丙泊酚的麻醉效果比较
Comparison of the anesthetic effects of remimazolam and propofol in painless gastroscopy for patients with gastroesophageal varices
摘要
Abstract
Objective To compare the anesthetic effects of remimazolam and propofol in painless gastroscopy for patients with gastroesophageal varices(GEV).Methods The clinical data of 98 patients with GEV who underwent precision treatment under pain-less gastroscopy in Affiliated Hospital of Qingdao University between February 2022 and February 2024 were retrospectively analyzed.There were 65 males and 33 females aged 18-75 years.The patients were divided into a remimazolam group and a propofol group ac-cording to different anesthesia methods,with 49 cases in each group.After 3 minutes of intravenous anesthesia induction,the patients received either 0.2 mg/kg remimazolam or 2 mg/kg propofol accordingly.Precision gastroscopy treatment began when eyelash reflex disappeared,with intraoperative top-ups of 0.05 mg/kg remimazolam or 0.5 mg/kg propofol administered as required.Data were re-corded at four time points:pre-induction baseline(T0),gastroscope passage through the pharynx(T1),5 minutes after procedure ini-tiation(T2),and immediately post-procedure(T3).Measured outcomes included sedation onset time,recovery time,discharge readi-ness time,and adverse reactions(including hiccups,dizziness,and nausea/vomiting).Results Compared with the propofol group,the remimazolam group exhibited significantly higher heart rate(HR)and mean arterial pressure(MAP)at T1,T2 and T3,and the pulse SpO2 and bispectral index(BIS)were also significantly higher at T1 and T2,with statistically significant differences(P<0.05).Compared with the propofol group,the remimazolam group showed significantly shorter recovery time[(5.39±1.12)min vs.(6.64±0.97)min]and discharge time[(19.53±3.24)min vs.(24.32±3.76)min;P<0.05],but there was no significant difference in the onset time of sedation between the two groups.The incidence of adverse reactions in the remimazolam group was significantly lower than that in the propofol group,with statistically significant differences in the incidence of coughing and hiccups[8(16.33%)vs.1(2.04%);13(26.53%)vs.1(2.04%)](P<0.05),but there was no signifi-cant difference in the incidence of bradycardia and body movement.Conclusions The application of remimazolam in the precision treatment of GEV patients under painless gastroscopy is significantly ef-fective,with less impact on hemodynamics than propofol,and the postoperative recovery is faster.关键词
瑞马唑仑/丙泊酚/食管胃底静脉曲张/无痛胃镜/精准治疗Key words
remimazolam/propofol/gastroesophageal varices/painless gastroscopy/precision treatment分类
医药卫生引用本文复制引用
齐立杰,冀翔宇,周赞宫,徐庆国,彭凯,赵丽双,张勇..食管胃底静脉曲张患者行无痛胃镜治疗瑞马唑仑与丙泊酚的麻醉效果比较[J].武警医学,2025,36(10):866-870,5.基金项目
国家自然科学基金(82272973) （82272973）
