武警医学2025，Vol.36Issue(10)：877-880,886,5.
双层探测器光谱CT肝细胞外体积分数评估非酒精性脂肪肝的临床价值
Clinical value of hepatic extracellular volume fraction derived from dual-layer detector spectral CT in assessing non-alcoholic fatty liver disease
张涛 1孟庆林 1田亚忠 1陈志晔1
作者信息
- 1. 572013 三亚,解放军总医院海南医院放射诊断科
- 折叠
摘要
Abstract
Objective To investigate the correlation between hepatic extracellular volume fraction(fECV)derived from dual-layer detector spectral CT(DLCT)and the liver fat content(Fat%)measured by quantitative CT(QCT),and to verify the feasibility of using fECV to assess the stages of non-alcoholic fatty liver disease(NAFLD).Methods A total of 165 NAFLD patients(87 males and 78 females)in Hainan Hospital of PLA General Hospital from January 2022 to December 2024 were included and categorized into mild(<14%Fat%,115 ROIs),moderate(14%-28%Fat%,528 ROIs),and severe(≥28%Fat%,347 ROIs)groups based on QCT measurement.fECV was obtained using DLCT(Philips IQon Spectral CT),and its diagnostic efficacy was evaluated via one-way ANOVA,Pearson correlation,and ROC curve.Results Significant negative correlations were observed between fECV and Fat%across all groups,with Fat%(0.10±0.04)and fECV(0.29±0.04)in the mild group,Fat%(0.21±0.08)and fECV(0.24±0.05)in the moderate group,Fat%(0.37±0.06)and fECV(0.14±0.06)in the severe group.The differences were statistically significant.Linear regression equation was Fat%=0.36-0.58×fECV(R2=0.668),indicating that for every 0.1 decrease in fECV,Fat%in-creased by 5.8%.ROC analysis showed that fECV had excellent diagnostic efficacy for moderate and above(AUC=0.873)and severe fatty liver(AUC=0.918),with a sensitivity>78%and specificity>81%.Conclusions The fECV derived from DLCT can be used as a reliable quantitative indicator for noninvasive staging of NAFLD,providing a new imaging strategy for clinical precision management.关键词
光谱CT/定量CT/双层探测器光谱CT/细胞外体积分数/脂肪肝Key words
spectral CT/quantitative CT/dual-layer detector spectral CT/extracellular volume fraction/fatty liver分类
医药卫生引用本文复制引用
张涛,孟庆林,田亚忠,陈志晔..双层探测器光谱CT肝细胞外体积分数评估非酒精性脂肪肝的临床价值[J].武警医学,2025,36(10):877-880,886,5.
