物理化学学报2025，Vol.41Issue(9)：158-168,11.DOI:10.1016/j.actphy.2025.100109
合理组装不同表面功能化碳点以增强近红外肿瘤光热治疗效果
Rationally assembling different surface functionalized carbon dots for enhanced near-infrared tumor photothermal therapy
摘要
Abstract
Carbon dots(CDs)have emerged as promising photothermal agents for near-infrared(NIR)-mediated tumor therapy due to their excellent biocompatibility and tunable optical properties.However,it is still unclear how to precisely control their assembly behavior to enhance NIR absorption and photothermal conversion efficiency.In this work,we present a hyper-assembled electron donor/acceptor CDs complex(S-d/a-CDs),constructed by integrating electron-donating CDs(d-CDs)with electron-withdrawing CDs(a-CDs).This configuration significantly enhances the NIR absorption capacity of S-d/a-CDs.Under 740 nm laser irradiation,S-d/a-CDs achieve a remarkable photothermal conversion efficiency(PTCE)of 65.8%.S-d/a-CDs exhibit negligible cytotoxicity and effective tumor accumulation capacity through intravenous administration,enabling complete tumor elimination after NIR laser irradiation.To our knowledge,this study is the first to exploit synergistic assembles of two types of CDs for photo-physical property engineering,establishing a groundbreaking paradigm for the development of advanced NIR-triggered photothermal materials.关键词
碳点/光热疗法/氢键/组装/电子供体/受体Key words
Carbon dots/Photothermal therapy/Hydrogen bond/Assemble/Donor/acceptor分类
化学化工引用本文复制引用
吴雪,刘钰鹏,王冰哲,李凌云,黎镇坚,王青城,程全胜,刑贵川,曲松楠..合理组装不同表面功能化碳点以增强近红外肿瘤光热治疗效果[J].物理化学学报,2025,41(9):158-168,11.基金项目
This work was financially supported by the Science and Technology Development Fund of Macau SAR(0139/2022/A3,0002/2024/TFP,0007/2021/AKP),the University of Macau-Dr.Stanley Ho Medical Development Foundation"Set Sail for New Horizons,Create the Future"Grant 2025(SHMDF-OIRFS/2025/001),and the National Natural Science Foundation of China(62205384). 澳门特别行政区科学技术发展基金(0139/2022/A3,0002/2024/TFP,0007/2021/AKP),澳门大学—何鸿燊博士医疗拓展基金会"扬帆起航·共创未来"2025年度资助(SHMDF-OIRFS/2025/001)及国家自然科学基金(62205384)资助项目 （0139/2022/A3,0002/2024/TFP,0007/2021/AKP）
