现代医药卫生2025，Vol.41Issue(10)：2257-2266,10.DOI:10.3969/j.issn.1009-5519.2025.10.001
服用阿司匹林与胆管癌发病风险的关系研究
Study on the relationship between aspirin use and the risk of cholangiocarcinoma
摘要
Abstract
Objective To investigate the relationship between aspirin use and the risk of cholangiocarci-noma(CCA)and its three subtypes.Methods A total of 380 patients with CCA diagnosed in the Second Affil-iated Hospital of Chongqing Medical University and the People's Hospital of Pengshui Miao and Tujia Auton-omous County were selected from January 2012 to June 2024,including 146 cases of intrahepatic cholangiocar-cinoma(iCCA),95 cases of perihilar cholangiocarcinoma(pCCA),139 cases of distal cholangiocarcinoma(dC-CA).The control group consisted of patients with no history of cancer,totaling 1 166 cases.Logistic regres-sion was used to analyze the data to explore the association between aspirin use,other risk factors and CCA risk.Results Aspirin use was significantly negatively associated with the risk of developing CCA[odds ratio(OR)=0.30,95%confidence interval(95%CI)0.18-0.50,P<0.001].Further analysis showed that aspirin use was associated with decreased risk of iCCA,pCCA and dCCA subtypes(OR=0.10,95%CI 0.03-0.30,P<0.001;OR=0.34,95%CI 0.14-0.86,P<0.022;OR=0.33,95%CI 0.15-0.73,P<0.006).Cholangi-tis was the most significant risk factor for dCCA(OR=81.43,95%CI 21.03-315.37,P<0.001).The inci-dence of iCCA and dCCA was associated with intrahepatic bile duct stones(OR=6.10,95%CI 1.35-27.57,P=0.019;OR=5.99,95%CI 1.17-30.55,P=0.031).While hepatitis B virus infection was a risk factor for iCCA and pCCA(OR=4.50,95%CI 2.57-7.88,P<0.001;OR=3.77,95%CI 1.92-7.41,P<0.001).Conclusion In the Chinese population,different risk factors have different degrees of harm to various CCAs.Taking aspirin can reduce the risk of CCA and three subtypes,which provides an important basis for reducing the burden of CCA disease.关键词
胆管癌/阿司匹林/肝内胆管癌/肝门部胆管癌/远端胆管癌Key words
Cholangiocarcinoma/Aspirin/Intrahepatic cholangiocarcinoma/Perihilar cholangio-carcinoma/Distal cholangiocarcinoma分类
医药卫生引用本文复制引用
张志强,周兴福,冉茂慧,代建华,代平川,游才虎,陈虹霖,李培志..服用阿司匹林与胆管癌发病风险的关系研究[J].现代医药卫生,2025,41(10):2257-2266,10.基金项目
重庆市科卫联合医学科研面上项目(2023MSXM010). （2023MSXM010）
