现代医药卫生2025，Vol.41Issue(10)：2276-2279,4.DOI:10.3969/j.issn.1009-5519.2025.10.004
血清sPD-L1与Irisin在膀胱癌中的表达及诊断价值
Expression and diagnostic value of serum sPD-L1 and Irisin in bladder cancer
摘要
Abstract
Objective To investigate the expression levels of serum soluble programmed death ligand 1(sPD-L1)and Irisin in bladder cancer and assess their combined diagnostic value.Methods A total of 47 pa-tients with bladder cancer(bladder cancer group)and 48 healthy controls(control group)admitted to the hos-pital from May 2019 to March 2023 were selected.The levels of serum sPD-L1 and Irisin were detected by en-zyme-linked immunosorbent assay(ELISA).Mann-Whitney U test was used to compare the differences be-tween the two groups,and the effectiveness of these two markers in the diagnosis of bladder cancer was evalu-ated by receiver operating characteristic(ROC)curve.Results The serum sPD-L1 level in the bladder cancer group was significantly higher than that in the control group,while the Irisin level was significantly lower than that in the control group,and the differences were statistically significant(P<0.05).The level of sPD-L1 in patients with invasive and high-grade bladder cancer was significantly higher than that in patients with non-in-vasive and low-grade bladder cancer,while the level of Irisin was significantly lower than that in the latter,and the differences were statistically significant(P<0.05).ROC curve analysis showed that the area under the curve(AUC)of sPD-L1 combined with Irisin was 0.80,the diagnostic efficiency was better than that of sPD-L1,and the sensitivity was better than that of sPD-L1 and Irisin.Conclusion The combined detection of ser-um sPD-L1 and Irisin has a high diagnostic value for bladder cancer,especially in high-grade and invasive blad-der cancer,which can provide an important auxiliary diagnostic basis for clinical practice.关键词
膀胱癌/可溶性程序性死亡配体1/鸢尾素/诊断价值Key words
Bladder cancer/Soluble programmed death ligand 1/Irisin/Diagnostic value分类
医药卫生引用本文复制引用
童金凤,江政松,唐秋燕,孙午,刘晓峰..血清sPD-L1与Irisin在膀胱癌中的表达及诊断价值[J].现代医药卫生,2025,41(10):2276-2279,4.基金项目
江西省卫生健康委员会科技计划项目(202311443). （202311443）
